Paulson Richard J
Department of Obstetrics and Gynecology, University of Southern California, Keck School of Medicine, Los Angeles, California.
Fertil Steril. 2017 Oct;108(4):555-557. doi: 10.1016/j.fertnstert.2017.08.023. Epub 2017 Sep 11.
In the current practice of IVF, the vast majority of cycles use some form of controlled ovarian stimulation before egg retrieval to increase the number of embryos available for transfer or cryopreservation. However, the optimal stimulation regimen has not been established. This month's Views and Reviews presents five different approaches to alternative ovarian stimulation strategies. These include mild stimulation regimens, modified natural cycles, stimulation with oral agents, in vitro maturation (in the absence of stimulation), and finally, a proposal for patient-tailored ovarian stimulation. As the treatment of infertility becomes more personalized, it is likely that standard, heavy-handed stimulation protocols will give way to simpler strategies, specifically tailored to each patient's individual characteristics and needs.
在当前的体外受精实践中,绝大多数周期在取卵前会采用某种形式的控制性卵巢刺激,以增加可用于移植或冷冻保存的胚胎数量。然而,最佳刺激方案尚未确定。本月的“观点与评论”介绍了五种不同的替代卵巢刺激策略方法。这些方法包括温和刺激方案、改良自然周期、口服药物刺激、体外成熟(无刺激),最后是针对患者定制的卵巢刺激方案。随着不孕症治疗变得更加个性化,标准化、高强度的刺激方案很可能会被更简单的策略所取代,这些策略是专门针对每个患者的个体特征和需求制定的。