Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, 350001, China.
Department of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, 350001, China.
Sci Rep. 2017 Sep 14;7(1):11625. doi: 10.1038/s41598-017-10414-x.
Young age (≤40 years) use to be considered an independent risk factor for the prognosis of women with early-stage breast cancer. We conducted a retrospective analysis to investigate this claim in a population of young patients who were stratified by molecular subtype. We identified 2,125 women with stage I to III breast cancer from the Fujian Medical University Union Hospital. Multivariable Cox proportional hazards models were used to analyze the relationship between age groups stratified by molecular subtype and 5-year disease-free survival (DFS), 5-year distant metastasis-free survival (DMFS), and 5-year breast cancer-specific survival (BCSS). Median follow-up time was 77 months. Patients ≤40 years of age presented with a significantly worse 5-year DFS and 5-year DMFS. In stratified analyses, young women with luminal A subtype disease were associated with a worse 5-year DFS, 5-year DMFS, and 5-year BCSS. Women with luminal B (Her2-) tumors showed a decrease in 5-year DFS and 5-year DMFS. Our findings support the hypothesis that young age seems to be an independent risk factor for the prognosis for breast cancer patients with the luminal A and luminal B (Her2-) subtypes but not in those with luminal B (Her2+), Her2 over-expression, and triple-negative disease.
年轻（≤40 岁）被认为是早期乳腺癌女性预后的独立危险因素。我们进行了一项回顾性分析，旨在研究分子亚型分层的年轻患者群体中是否存在这种情况。我们从福建医科大学附属协和医院确定了 2125 名 I 期至 III 期乳腺癌患者。多变量 Cox 比例风险模型用于分析按分子亚型分层的年龄组与 5 年无病生存率（DFS）、5 年远处无复发生存率（DMFS）和 5 年乳腺癌特异性生存率（BCSS）之间的关系。中位随访时间为 77 个月。≤40 岁的患者 5 年 DFS 和 5 年 DMFS 明显较差。分层分析显示，年轻女性的 luminal A 型疾病与较差的 5 年 DFS、5 年 DMFS 和 5 年 BCSS 相关。luminal B（Her2-）肿瘤患者的 5 年 DFS 和 5 年 DMFS 下降。我们的研究结果支持这样的假设，即年轻似乎是 luminal A 和 luminal B（Her2-）亚型乳腺癌患者预后的独立危险因素，但不是 luminal B（Her2+）、Her2 过表达和三阴性疾病患者的预后独立危险因素。
