微小RNA-210通过促进雪旺细胞的增殖和迁移来促进周围神经再生。
MicroRNA-210 contributes to peripheral nerve regeneration through promoting the proliferation and migration of Schwann cells.
作者信息
Zhang Xiaona, Gong Xu, Qiu Jinpeng, Zhang Yang, Gong Fengyan
机构信息
Department of Anesthesiology, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
Department of Hand and Foot Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
出版信息
Exp Ther Med. 2017 Oct;14(4):2809-2816. doi: 10.3892/etm.2017.4869. Epub 2017 Aug 2.
Peripheral nerve injury impacts the daily life of affected individuals. MicroRNA (miR)-210 is a multifunctional miR and has effects on the proliferation, migration and differentiation of cells. However, whether miR-210 has effects on peripheral nerve regeneration has remained elusive. In the present study, the miR-210 levels in a rat model of sciatic nerve injury were evaluated by reverse-transcription quantitative PCR and the effects of miR-210 on the proliferation and migration of Schwann cells were explored. Elevated miR-210 levels were discovered in the sciatic nerve injury rat model. miR-210 mimics were found to promote the proliferation and migration of Schwann cells, while miR-210 inhibitor was found to inhibit the proliferation and migration of Schwann cells. Further study showed that miR-210 had effects on the expression of growth-associated protein-43, myelin-associated glycoprotein and myelin basic protein. These results showed that miR-210 had effects on the proliferation and migration of Schwann cells and may be involved in the peripheral nerve regeneration.
周围神经损伤会影响受影响个体的日常生活。微小RNA（miR）-210是一种多功能微小RNA，对细胞的增殖、迁移和分化有影响。然而，miR-210是否对周围神经再生有影响仍不清楚。在本研究中，通过逆转录定量PCR评估坐骨神经损伤大鼠模型中的miR-210水平，并探讨miR-210对雪旺细胞增殖和迁移的影响。在坐骨神经损伤大鼠模型中发现miR-210水平升高。发现miR-210模拟物可促进雪旺细胞的增殖和迁移，而miR-210抑制剂可抑制雪旺细胞的增殖和迁移。进一步研究表明，miR-210对生长相关蛋白-43、髓鞘相关糖蛋白和髓鞘碱性蛋白的表达有影响。这些结果表明，miR-210对雪旺细胞的增殖和迁移有影响，可能参与周围神经再生。
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