Haydardedeoğlu Bülent, Işık Ahmet Zeki, Bulgan Kılıçdağ Esra
Başkent University Faculty of Medicine, Department of Obstetrics and Gynecology, Adana, Turkey.
İzmir University Faculty of Medicine, Department of Obstetrics and Gynecology, İzmir, Turkey.
Turk J Obstet Gynecol. 2015 Jun;12(2):60-65. doi: 10.4274/tjod.32656. Epub 2015 Jun 15.
To evaluate to the efficacy of testosterone, dehydroepiandrosterone (DHEA) and growth hormone (GH) supplementations in patients with diminished ovarian reserve (DOR) in assisted reproductive technology (ART) cycles.
A retrospective cohort including 33 women with 81 ART cycles were aged and ovarian reserve matched 52 women with 102 conventional in vitro fertilization (IVF)/intra-cytoplasmic sperm injection (ICSI) protocol. Administration of DHEA for 12 weeks and transdermal testosterone for 4 weeks as pretreatment adjuvant and luteal start GH in DOR patient treatment arm compared to conventional IVF/ICSI cycles.
The number of follicles >14 mm, number of oocytes, number of metaphase 2 oocytes and fertilisation rate were significantly higher in ISIK protocol (IP). The clinical pregnancy rate (CPR) per embryo transfer of the IP was 38.2% (13/34). The cancellation rate of cycles decreased significantly from 54.5 % (24/44) to 8.1% (3/37) with the IP, while the OPR was 35.3% (12/34).
Our study has shown that even the poorest responders could achieve clinical pregnancy after inducing ovarian folliculogenesis with a combination of transdermal testosterone, DHEA and GH.
评估在辅助生殖技术（ART）周期中，补充睾酮、脱氢表雄酮（DHEA）和生长激素（GH）对卵巢储备功能减退（DOR）患者的疗效。
一项回顾性队列研究，纳入33例接受81个ART周期治疗的女性，与52例接受102个传统体外受精（IVF）/卵胞浆内单精子注射（ICSI）方案治疗的女性进行年龄和卵巢储备匹配。在DOR患者治疗组中，作为预处理辅助手段，给予12周的DHEA和4周的经皮睾酮治疗，并在黄体期开始使用GH，与传统IVF/ICSI周期进行比较。
在ISIK方案（IP）中，直径>14mm的卵泡数量、卵母细胞数量、MII期卵母细胞数量和受精率显著更高。IP组每次胚胎移植的临床妊娠率（CPR）为38.2%（13/34）。采用IP方案后，周期取消率从54.5%（24/44）显著降至8.1%（3/37），而着床率为35.3%（12/34）。
我们的研究表明，即使是反应最差的患者，通过联合经皮睾酮、DHEA和GH诱导卵巢卵泡生成后，也能实现临床妊娠。
