Şakirahmet Şen Dilek, Gökmen Karasu Ayşe Filiz, Özgün Geçer Melin, Karadayı Nimet, Ablan Yamuç Elif
Lütfi Kırdar Research and Training Hospital, Department of Pathology, İstanbul, Turkey.
Bezmialem Vakıf University Faculty of Medicine, Department of Obstetrics and Gynecology, İstanbul, Turkey.
Turk J Obstet Gynecol. 2016 Mar;13(1):37-41. doi: 10.4274/tjod.22220. Epub 2016 Mar 10.
Ovarian metasteses are often mistaken for primary adenocarcinoma. Studies conducted in recent years have focused on a search for an immunohistochemical marker to aid the differential diagnosis primary and metastatic ovarian carcinoma. Our study objective was to study the usefulness of Wilms tumor 1 (WT 1) antigen in this context.
The study was conducted at the pathology clinic of Lütfi Kırdar Training and Research Hospital. Deparaffinated blocks of 40 epithelial ovarian tumors, 40 colon adenocarcinomas, and 35 cases of omentum metastases were studied. Cytokeratin 7 (CK 7), cytokeratin 20 (CK 20), and WT 1 were applied to all specimens.
All ovarian adenocarcinomas were stained with CK 7 (100%). Colorectal adenocarcinomas were stained positive with CK 20 in 87.5% of cases. Primary ovarian adenocarcinomas stained positive with WT 1 in 82.5% of the cases and none of the colorectal adenocarcinomas showed staining with WT 1 (0%).
WT 1 can be used in conjuction with CK 7 in the differential diagnosis of ovarian carcinomas.
卵巢转移瘤常被误诊为原发性腺癌。近年来开展的研究聚焦于寻找一种免疫组化标志物，以辅助鉴别原发性和转移性卵巢癌。我们的研究目的是探讨威尔姆斯瘤1（WT1）抗原在此方面的用途。
该研究在吕特菲·基尔达尔培训与研究医院病理科进行。对40例上皮性卵巢肿瘤、40例结肠腺癌及35例大网膜转移瘤的脱石蜡包块进行研究。对所有标本应用细胞角蛋白7（CK7）、细胞角蛋白20（CK20）和WT1。
所有卵巢腺癌均被CK7染色（100%）。87.5%的结肠腺癌被CK20染色呈阳性。82.5%的原发性卵巢腺癌被WT1染色呈阳性，而所有结肠腺癌均未显示WT1染色（0%）。
WT1可与CK7联合用于卵巢癌的鉴别诊断。
