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孕早期胎儿主动脉多普勒检查用于血红蛋白病

First trimester fetal aortic Doppler for hemoglobinopathies.

作者信息

Çetin Cihan, Büyükkurt Selim, Dündar Yenilmez Ebru, Özsürmeli Mehmet, Sucu Mete, Demir Cansun

机构信息

Çukurova University Faculty of Medicine, Department of Obstetrics and Gynecology, Adana, Turkey.

Çukurova University Faculty of Medicine, Department of Medical Biochemistry, Adana, Turkey.

出版信息

Turk J Obstet Gynecol. 2016 Jun;13(2):75-79. doi: 10.4274/tjod.24381. Epub 2016 Jun 15.

DOI:10.4274/tjod.24381
PMID:28913096
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5558342/
Abstract

OBJECTIVE

To evaluate fetal aortic Doppler for the prenatal diagnosis of hemoglobinopathies in the first trimester of pregnancy.

MATERIALS AND METHODS

Between January and November 2014, a total of 108 patients were enrolled in the study. The couples were carriers of either alpha/beta thalassemia, sickle cell disease or combined carriers of these and were admitted to Çukurova University Faculty of Medicine, Department of Obstetrics and Gynecology Prenatal Diagnosis Center. One hour before the chorionic villus sampling (CVS), patients were evaluated using fetal aortic Doppler. Pulsatility index, peak systolic velocity, and heart rate were noted.

RESULTS

There were no statistically significant differences in Doppler indices between different groups of CVS results when compared with the healthy controls.

CONCLUSION

Fetal aortic Doppler investigation was found to be ineffective for the prenatal diagnosis of hemoglobinopathies.

摘要

目的

评估妊娠早期胎儿主动脉多普勒检查在血红蛋白病产前诊断中的应用。

材料与方法

2014年1月至11月，共有108例患者纳入本研究。这些夫妇为α/β地中海贫血、镰状细胞病的携带者，或为这些疾病的联合携带者，并被收治于库库洛瓦大学医学院妇产科产前诊断中心。在绒毛取样（CVS）前1小时，使用胎儿主动脉多普勒对患者进行评估。记录搏动指数、收缩期峰值速度和心率。

结果

与健康对照组相比，不同CVS结果组之间的多普勒指标无统计学显著差异。

结论

胎儿主动脉多普勒检查被发现对血红蛋白病的产前诊断无效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d60f/5558342/b5aef725e974/TJOD-13-75-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d60f/5558342/b5aef725e974/TJOD-13-75-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d60f/5558342/b5aef725e974/TJOD-13-75-g3.jpg

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