Gökdemir İrem Eda, Evliyaoğlu Özlem, Çoşkun Buğra
Yenimahalle Training and Research Hospital, Clinic of Obstetrics and Gynecology, Ankara, Turkey.
Zekai Tahir Burak Women's Health Training and Research Hospital, Clinic of Obstetrics and Gynecology, Ankara, Turkey.
Turk J Obstet Gynecol. 2016 Sep;13(3):149-153. doi: 10.4274/tjod.57701. Epub 2016 Sep 15.
Preeclampsia is a complex disease that increases both maternal and fetal morbidity and mortality in both developed and developing countries. It complicates around 5-10% of all pregnancies..The pathophysiology of preeclampsia includes both maternal and fetal/placental factors. Implantation of embryo and placentation are crucial steps for development of pregnancy involving trophoblast invasion. Abnormalities of spiral artery invasion, trophoblast function, inflammatory process, and biologic functions of angiogenic/anti-angiogenic factors early in pregnancy result in pregnancy diseases, including preeclampsia. genes are members of the family of matrix metalloproteinase, which have important tasks in extracellular matrix (ECM) degradation and repair processes. The roles of in preeclampsia may include regulation of spiral artery invasion and ECM arrangement of the placenta.
子痫前期是一种复杂的疾病，在发达国家和发展中国家都会增加孕产妇和胎儿的发病率及死亡率。它使约5%至10%的妊娠复杂化。子痫前期的病理生理学包括母体和胎儿/胎盘因素。胚胎着床和胎盘形成是涉及滋养层侵入的妊娠发育的关键步骤。妊娠早期螺旋动脉侵入、滋养层功能、炎症过程以及血管生成/抗血管生成因子的生物学功能异常会导致包括子痫前期在内的妊娠疾病。基因是基质金属蛋白酶家族的成员，在细胞外基质（ECM）降解和修复过程中具有重要作用。其在子痫前期中的作用可能包括调节螺旋动脉侵入和胎盘的ECM排列。
