女性生殖系统疾病中的一种新型生物标志物候选物：含血小板反应蛋白基序的金属蛋白酶（ADAMTS）。
A new biological marker candidate in female reproductive system diseases: Matrix metalloproteinase with thrombospondin motifs (ADAMTS).
作者信息
Demircan Kadir, Cömertoğlu İsmail, Akyol Sümeyya, Yiğitoğlu Beyza Nur, Sarıkaya Esma
机构信息
Department of Medical Biology, Turgut Özal University Faculty of Medicine, Ankara, Turkey.
Department of Medical Genetics, Turgut Özal University Faculty of Medicine, Ankara, Turkey.
出版信息
J Turk Ger Gynecol Assoc. 2014 Dec 1;15(4):250-5. doi: 10.5152/jtgga.2014.14206. eCollection 2014.
Abstract
Playing a key role in the pathophysiology of many diseases, A Disintegrin-like and Metalloproteinase with Thrombospondin type-1 motif (ADAMTS) proteinases have been attracted more attention in obstetrics and gynecology. First discovered in 1997, this zinc-dependent proteinase family has 19 members today. These enzymes, which are located in the extracellular matrix (ECM), have a lot of very important functions, like matrix formation and resorption, angiogenesis, ovulation, and coagulation. In addition, in the pathogenesis of cancer, inflammation, arthritis, and connective tissue diseases, ADAMTS proteinases have crucial roles. The purpose of this review is to collect previous studies about obstetrics and gynecology that are related to ADAMTS enzymes and discuss the subject in many aspects to give an idea to the investigators who are interested in the subject.
摘要
具有血小板反应蛋白-1型基序的解整合素样金属蛋白酶（ADAMTS）蛋白酶在多种疾病的病理生理学中发挥关键作用，在妇产科领域受到了更多关注。该蛋白酶家族于1997年首次被发现，如今已拥有19个成员。这些位于细胞外基质（ECM）中的酶具有许多非常重要的功能，如基质形成与吸收、血管生成、排卵和凝血。此外，在癌症、炎症、关节炎和结缔组织疾病的发病机制中，ADAMTS蛋白酶也起着关键作用。本综述的目的是收集以往与ADAMTS酶相关的妇产科研究，并从多个方面对该主题进行讨论，为对该主题感兴趣的研究人员提供思路。
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