Çağlar Aytaç Pınar, Haydardedeoğlu Bülent, Özdemir Halis, Bulgan Kılıçdağ Esra
Başkent University Faculty of Medicine, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Adana, Turkey.
Başkent University Faculty of Medicine, Department of Obstetrics and Gynecology, Division of Perinatology, Adana, Turkey.
Turk J Obstet Gynecol. 2017 Jun;14(2):76-81. doi: 10.4274/tjod.23540. Epub 2017 Jun 15.
To evaluate the effects of a gonadotropin releasing hormone agonist (GnRHa) injection prior to embryo transfer on implantation and pregnancy rate.
We performed a retrospective analysis of patients undergoing in vitro fertilization (IVF) therapy with and without GnRHa preinstallation into the uterine cavity just before embryo transfer between January 2012 and March 2013 in a single IVF center of a university hospital. Patients were evaluated based upon implantation, pregnancy, live birth, and miscarriage rates.
GnRHa was injected into the uterine cavity of 108 patients prior to embryo transfer which were regarded as study group. One thousand forty-seven patients who were not injected GnRHa were regarded as the control group. Pregnancy rates were 44.4% and 41.7% in the GnRHa and control groups, respectively. Live birth rates were 27.8% and 26.1%, miscarriage rates were 15.7% and 15.7%, and implantation rates were 31% and 30%, respectively and there were no difference between groups statistically (p>0.05).
No statistically significant differences in implantation, pregnancy, live birth, or miscarriage rates were observed in patients treated with GnRHa prior to embryo transfer, relative to the controls. Therefore, GnRHa injection into the uterine cavity prior to embryo transfer is not recommended as a means of increasing implantation or pregnancy rates in IVF. However, prospective randomized controlled studies are needed to clarify the effect of GnRHa instillation in the uterine cavity for embryo implantation in IVF.
评估胚胎移植前注射促性腺激素释放激素激动剂（GnRHa）对着床率和妊娠率的影响。
我们对一所大学医院的单一体外受精（IVF）中心在2012年1月至2013年3月期间接受IVF治疗的患者进行了回顾性分析，这些患者在胚胎移植前有或没有在子宫腔内预先安装GnRHa。根据着床率、妊娠率、活产率和流产率对患者进行评估。
108例患者在胚胎移植前在子宫腔内注射了GnRHa，这些患者被视为研究组。1047例未注射GnRHa的患者被视为对照组。GnRHa组和对照组的妊娠率分别为44.4%和41.7%。活产率分别为27.8%和26.1%，流产率分别为15.7%和15.7%，着床率分别为31%和30%，两组之间在统计学上无差异（p>0.05）。
与对照组相比，胚胎移植前接受GnRHa治疗的患者在着床率、妊娠率、活产率或流产率方面未观察到统计学上的显著差异。因此，不建议在胚胎移植前在子宫腔内注射GnRHa作为提高IVF着床率或妊娠率的方法。然而，需要进行前瞻性随机对照研究以阐明在子宫腔内滴注GnRHa对IVF胚胎着床的影响。
