Erkan Gönül, Tayyar Ahter Tanay, Açmaz Gökhan, Müderris İptisam İpek, Başkol Gülden, Bayram Fahri
Private Hüma Hospital, Clinic of Obstetrics and Gynecology, Kayseri, Turkey.
Zeynep Kamil Maternity and Children's Diseases Training and Research Hospital, Clinic of Obstetrics and Gynecology, İstanbul, Turkey.
Turk J Obstet Gynecol. 2017 Jun;14(2):89-93. doi: 10.4274/tjod.61224. Epub 2017 Jun 15.
Insulin resistance (IR) seems to be the main pathogenic factor in polycystic ovary syndrome (PCOS). Adiponectin and tumor necrosis factor-alpha (TNF-α) are important in IR. The aim of this study was to evaluate the correlations of osteocalcin, adiponectin, and TNF-α with IR in PCOS.
A total of 60 women were divided into two groups. The first group constituted 44 patients with PCOS and the control group comprised 16 healthy women. Osteocalcin, adiponectin, TNF-α levels, body mass index (BMI), and IR in the fasting state were assessed and correlations of these parameters were evaluated.
Homeostasis model assessment (HOMA)-IR, adiponectin, osteocalcin, and androstenedione levels were significantly increased in the PCOS group. A moderate positive correlation between BMI and HOMA-IR, a moderate negative correlation between TNF-α and osteocalcin, and a mild negative correlation between adiponectin and BMI were detected in PCOS.
Osteocalcin may have impact on adiponectin, TNF-α, and IR levels in PCOS. Different osteocalcin levels in patients with PCOS may be responsible for explaining PCOS heterogeneity.
胰岛素抵抗（IR）似乎是多囊卵巢综合征（PCOS）的主要致病因素。脂联素和肿瘤坏死因子-α（TNF-α）在胰岛素抵抗中起重要作用。本研究旨在评估骨钙素、脂联素和TNF-α与PCOS患者胰岛素抵抗的相关性。
总共60名女性被分为两组。第一组由44例PCOS患者组成，对照组包括16名健康女性。评估空腹状态下骨钙素、脂联素、TNF-α水平、体重指数（BMI）和胰岛素抵抗情况，并评估这些参数之间的相关性。
PCOS组中稳态模型评估（HOMA）-IR、脂联素、骨钙素和雄烯二酮水平显著升高。在PCOS患者中检测到BMI与HOMA-IR之间存在中度正相关，TNF-α与骨钙素之间存在中度负相关，脂联素与BMI之间存在轻度负相关。
骨钙素可能对PCOS患者的脂联素、TNF-α和胰岛素抵抗水平有影响。PCOS患者不同的骨钙素水平可能是解释PCOS异质性的原因。
