Centre of Reproductive Medicine, Zhuhai Women and Children's Hospital and Health Institute, Zhuhai 519000, People's Republic of China.
Eur J Obstet Gynecol Reprod Biol. 2011 Nov;159(1):148-50. doi: 10.1016/j.ejogrb.2011.07.012. Epub 2011 Sep 9.
The purpose of this study was to investigate chronic inflammation in the peripheral blood and ovaries of patients with polycystic ovary syndrome (PCOS). 86 PCOS patients and 50 controls were randomly enrolled in the study. Serum follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone (T), blood routine test, lipid metabolism index, inflammation cytokines were detected. Ovary samples from PCOS group and control group were collected for macrophage and lymphocyte immunohistochemistry staining. Patients with PCOS showed significantly higher serum CRP, lymphocytes, monocytes, eosinophilic granulocytes, as well as higher triglycerides (TG), TNF-α and IL-6. PCOS ovary had greater number of macrophages and lymphocytes immersed throughout. In conclusion, PCOS patients exhibited hypertriglyceridemia and chronic inflammation, with elevated peripheral lymphocytes, monocytes, and eosinophilic granulocytes. In addition, their ovaries showed persistent chronic inflammation with a larger number of inflammatory cells immersed.
本研究旨在探讨多囊卵巢综合征（PCOS）患者外周血和卵巢的慢性炎症。随机纳入 86 例 PCOS 患者和 50 例对照者。检测血清卵泡刺激素（FSH）、黄体生成素（LH）、睾酮（T）、血常规、脂代谢指标、炎症细胞因子。收集 PCOS 组和对照组的卵巢标本进行巨噬细胞和淋巴细胞免疫组化染色。PCOS 患者血清 CRP、淋巴细胞、单核细胞、嗜酸性粒细胞显著升高，三酰甘油（TG）、TNF-α、IL-6 也升高。PCOS 卵巢中有更多浸润的巨噬细胞和淋巴细胞。总之，PCOS 患者表现出高甘油三酯血症和慢性炎症，外周血淋巴细胞、单核细胞和嗜酸性粒细胞增多。此外，其卵巢存在持续的慢性炎症，浸润的炎症细胞较多。
