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法尼醇抑制翻译过程以限制在……中的生长和丝状化。 （注：原文中“and”后面缺少具体内容，翻译可能不够完整准确）

Farnesol inhibits translation to limit growth and filamentation in and .

作者信息

Egbe Nkechi E, Dornelles Tawni O, Paget Caroline M, Castelli Lydia M, Ashe Mark P

机构信息

Division of Molecular and Cellular Function, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Michael Smith Building, Oxford Rd., Manchester, M13 9PT, United Kingdom.

Current address: Department of Biological Sciences, Nigerian Defence Academy, PMB 2109, Kaduna, Nigeria.

出版信息

Microb Cell. 2017 Sep 4;4(9):294-304. doi: 10.15698/mic2017.09.589.

DOI:10.15698/mic2017.09.589
PMID:28913344
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5597792/
Abstract

is a polymorphic yeast where the capacity to switch between yeast and filamentous growth is critical for pathogenicity. Farnesol is a quorum-sensing sesquiterpene alcohol that, via regulation of specific signalling and transcription components, inhibits filamentous growth in . Here we show that farnesol also inhibits translation at the initiation step in both and . In contrast to fusel alcohols, that target the eukaryotic initiation factor 2B (eIF2B), farnesol affects the interaction of the mRNA with the small ribosomal subunit leading to reduced levels of the 48S preinitiation ribosomal complex in . Therefore, farnesol targets a different step in the translation pathway than fusel alcohols to elicit a completely opposite physiological outcome by negating filamentous growth.

摘要

是一种多态性酵母，在酵母和丝状生长之间切换的能力对致病性至关重要。法尼醇是一种群体感应倍半萜醇，通过调节特定的信号和转录成分，抑制其丝状生长。在这里，我们表明法尼醇在和中也在起始步骤抑制翻译。与靶向真核起始因子2B（eIF2B）的杂醇不同，法尼醇影响mRNA与小核糖体亚基的相互作用，导致中48S起始前核糖体复合物水平降低。因此，法尼醇靶向翻译途径中与杂醇不同的步骤，通过否定丝状生长引发完全相反的生理结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/298c/5597792/59d8578679cd/mic-04-294-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/298c/5597792/cc9d19c49ff8/mic-04-294-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/298c/5597792/5e93f8f938d6/mic-04-294-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/298c/5597792/309f4be1353d/mic-04-294-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/298c/5597792/61b27dac835f/mic-04-294-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/298c/5597792/59d8578679cd/mic-04-294-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/298c/5597792/cc9d19c49ff8/mic-04-294-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/298c/5597792/5e93f8f938d6/mic-04-294-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/298c/5597792/309f4be1353d/mic-04-294-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/298c/5597792/61b27dac835f/mic-04-294-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/298c/5597792/59d8578679cd/mic-04-294-g05.jpg

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