Crowder J M, Bradford H F
Biochemistry Department, Imperial College of Science and Technology, London, U.K.
Eur J Pharmacol. 1987 Nov 17;143(3):343-52. doi: 10.1016/0014-2999(87)90458-4.
Noradrenaline and dopamine (0.1-100 microM) inhibited 45Ca2+ uptake and glutamate release induced by veratrine (25 microM) in cortical and striatal slices but were without effect when added alone. Each parameter was inhibited in a dose-dependent manner by noradrenaline in cortical slices (IC50 = 0.05 microM) and by dopamine in striatal slices (IC50 = 0.08 microM). Noradrenaline (0.01-100 microM) was without influence on veratrine-induced 45Ca2+ influx or glutamate release in the striatal preparation, and likewise dopamine was inactive in cortex slices. The use of adrenoceptor antagonists suggests that the action of noradrenaline is mediated by the alpha 2-receptor which is thought to be adenylate cyclase linked. Dopamine appeared to be acting through the D-2 receptor.
去甲肾上腺素和多巴胺（0.1 - 100微摩尔）可抑制藜芦碱（25微摩尔）诱导的皮质和纹状体切片中45Ca2+摄取及谷氨酸释放，但单独添加时无作用。在皮质切片中，去甲肾上腺素以剂量依赖方式抑制各参数（IC50 = 0.05微摩尔）；在纹状体切片中，多巴胺以剂量依赖方式抑制各参数（IC50 = 0.08微摩尔）。去甲肾上腺素（0.01 - 100微摩尔）对藜芦碱诱导的纹状体标本中45Ca2+内流或谷氨酸释放无影响，同样，多巴胺对皮质切片也无活性。使用肾上腺素能受体拮抗剂表明，去甲肾上腺素的作用由α2受体介导，该受体被认为与腺苷酸环化酶相联系。多巴胺似乎通过D - 2受体起作用。
