惊厥剂儿茶酚对大鼠脑片神经递质摄取和释放的影响。
The effect of the convulsant agent, catechol, on neurotransmitter uptake and release in rat brain slices.
作者信息
Minchin M C, Pearson G
出版信息
Br J Pharmacol. 1981 Nov;74(3):715-21. doi: 10.1111/j.1476-5381.1981.tb10483.x.
Abstract
1 The effect of catechol on uptake and K+-stimulated release of gamma-aminobutyric acid (GABA), D-aspartate, noradrenaline and acetylcholine has been studied in slices of cerebral cortex and thalamus. 2 Low concentrations of catechol did not influence the uptake of any of the neurotransmitters in either brain area. 3 Noradrenaline release was unaffected by catechol. 4 Acetylcholine release from both cortical and thalamic slices was inhibited by high concentrations of catechol. This phenomenon is unlikely to be related to catechol-induced convulsions. 5 Catechol (100 microM) inhibited GABA release from cortical slices by 28%. However, at a concentration of 10 microM catechol enhanced the release of D-aspartate from thalamic slices by over 100%. 6 Potentiated release of excitatory amino acid transmitters may contribute to the enhanced excitability of thalamic cells which occurs during sensory myoclonus induced by low doses of catechol.
摘要
- 已经在大脑皮层和丘脑切片中研究了儿茶酚对γ-氨基丁酸（GABA）、D-天冬氨酸、去甲肾上腺素和乙酰胆碱摄取及钾离子刺激释放的影响。2. 低浓度的儿茶酚对两个脑区中任何一种神经递质的摄取均无影响。3. 儿茶酚对去甲肾上腺素的释放没有影响。4. 高浓度的儿茶酚抑制了皮层和丘脑切片中乙酰胆碱的释放。这种现象不太可能与儿茶酚诱导的惊厥有关。5. 儿茶酚（100微摩尔）使皮层切片中GABA的释放减少了28%。然而，在10微摩尔的浓度下，儿茶酚使丘脑切片中D-天冬氨酸的释放增加了100%以上。6. 兴奋性氨基酸递质释放的增强可能导致在低剂量儿茶酚诱导的感觉性肌阵挛期间丘脑细胞兴奋性的增强。
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