循环正常 IgG 作为调节性 T 细胞的刺激物：来自静脉注射免疫球蛋白的启示。
Circulating Normal IgG as Stimulator of Regulatory T Cells: Lessons from Intravenous Immunoglobulin.
机构信息
Institut National de la Santé et de la Recherche Médicale Unité 1138, Paris, F-75006, France; Centre de Recherche des Cordeliers, Equipe-Immunopathologie et Immunointervention Thérapeutique, Paris, F-75006, France; Sorbonne Universités, UPMC University Paris 06, UMR S 1138, Paris, F-75006, France; Present Address: Pfizer Inc, Pearl River, NY, USA.
Institut National de la Santé et de la Recherche Médicale Unité 1138, Paris, F-75006, France; Centre de Recherche des Cordeliers, Equipe-Immunopathologie et Immunointervention Thérapeutique, Paris, F-75006, France; Sorbonne Universités, UPMC University Paris 06, UMR S 1138, Paris, F-75006, France; Université Paris Descartes, Sorbonne Paris Cité, UMR S 1138, Paris, F-75006, France.
出版信息
Trends Immunol. 2017 Nov;38(11):789-792. doi: 10.1016/j.it.2017.08.008. Epub 2017 Sep 12.
Intravenous immunoglobulin (IVIG), a pooled normal IgG formulation prepared from thousands of healthy donors' plasma, is extensively used for the immunotherapy of autoimmune and inflammatory disorders. Recent reports demonstrate that IVIG exerts anti-inflammatory actions by stimulating the activation and expansion of regulatory T (Treg) cells by multiple mechanisms via antigen-presenting cells (APCs).
静脉注射免疫球蛋白（IVIG）是一种从数千名健康供体的血浆中制备的混合正常 IgG 制剂，广泛用于治疗自身免疫和炎症性疾病的免疫疗法。最近的报告表明，IVIG 通过抗原呈递细胞（APC）通过多种机制刺激调节性 T（Treg）细胞的激活和扩增来发挥抗炎作用。
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