Kusuhara K, Sonoda S, Takahashi K, Tokugawa K, Fukushige J, Ueda K
Department of Pediatrics, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Int J Cancer. 1987 Dec 15;40(6):755-7. doi: 10.1002/ijc.2910400607.
Okinawa prefecture is one of the endemic areas for adult T-cell leukemia/lymphoma (ATLL) in Japan. In this study, 2,013 serum specimens drawn serially over a period of 15 years (1968-1983) from 311 mother/child pairs in Okinawa were tested for antibodies to human T-cell leukemia virus type I (HTLV-I) by enzyme-linked immunosorbent assay and by indirect immunofluorescence. The prevalence rate of HTLV-I antibodies was 20.9% (65 cases) in the mothers and 3.2% (10 cases) in the children. Of the 65 seropositive mothers, 10 (15.4%) had seropositive children. This study revealed a significant difference between the prevalence rates of HTLV-I antibodies in mothers and children. In addition, children born to seropositive mothers had acquired their HTLV-I antibodies by the age of 3 years, and were still seropositive at the age of 18 years. No initially seronegative child was found to have seroconverted during the period investigated.
冲绳县是日本成人T细胞白血病/淋巴瘤（ATLL）的流行地区之一。在本研究中，采用酶联免疫吸附测定法和间接免疫荧光法，对1968年至1983年期间从冲绳县311对母婴中连续采集的2013份血清标本进行了人类T细胞白血病病毒I型（HTLV-I）抗体检测。母亲中HTLV-I抗体的流行率为20.9%（65例），儿童中为3.2%（10例）。在65例血清阳性母亲中，10例（15.4%）的孩子血清阳性。本研究揭示了母亲和儿童中HTLV-I抗体流行率之间的显著差异。此外，血清阳性母亲所生的孩子在3岁时已获得HTLV-I抗体，18岁时仍为血清阳性。在调查期间，未发现最初血清阴性的儿童发生血清转化。
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