Helm G, Ekman R, Owman C
Department of Obstetrics and Gynecology, University of Lund, Sweden.
Int J Fertil. 1987 Nov-Dec;32(6):467-71.
Levels of the neuropeptide VIP were measured by radioimmunoassay in the isthmus, ampulla, and fimbriated end of the human fallopian tube during the follicular, ovulatory, and luteal phases as defined by plasma estradiol and progesterone concentrations. The regional concentration of VIP was in the order isthmus greater than ampulla greater than fimbriae. The VIP concentration increased by 170% from the follicular through the ovulatory to the luteal phase in the isthmus. Such a tendency was seen also in the ampulla when the peptide level was expressed in terms of the total regional content. In fact, when expressed as total content, VIP was highest in the ampulla at all cyclic stages. Since there are no major fluctuations in the water content of the tubal tissues in the three phases, the observed changes in VIP levels represent real fluctuations at the neural level in a manner similar to that previously shown for the neurotransmitter norepinephrine.
通过放射免疫分析法测定了在由血浆雌二醇和孕酮浓度所定义的卵泡期、排卵期和黄体期，人输卵管峡部、壶腹部和伞端的神经肽血管活性肠肽（VIP）水平。VIP的区域浓度顺序为峡部大于壶腹部大于伞端。峡部的VIP浓度从卵泡期到排卵期再到黄体期增加了170%。当以区域总含量来表示肽水平时，壶腹部也出现了这种趋势。实际上，当以总含量表示时，VIP在所有周期阶段在壶腹部都是最高的。由于在这三个阶段输卵管组织的含水量没有重大波动，因此观察到的VIP水平变化代表了神经水平上的真实波动，其方式类似于先前对神经递质去甲肾上腺素所显示的那样。
