Mismar Ayman A, Mahseeri Mohammad I, Al-Ghazawi Mutasim A, Obeidat Firas W, Albsoul Mai N, Al-Qudah Mohammad S, Albsoul Nader M
Department of Surgery, Faculty of Medicine, The University of Jordan, Amman, Jordan. E-mail.
Saudi Med J. 2017 Oct;38(10):994-999. doi: 10.15537/smj.2017.10.20294.
To study the effect of local wound infiltration with and without adrenaline on pain perception after thyroidectomy using the visual analog score (VAS). Methods: A prospective randomized controlled double-blinded study was conducted between May 2015 and June 2016 at The University of Jordan Hospital, Amman, Jordan. Eighty-nine patients undergoing planned thyroidectomy were included in the study. Patients were divided randomly into 3 groups: Group A, local wound infiltration with bupivacaine 0.5% was administered; Group B, bupivacaine 0.5% with adrenaline was administered; Group C (control), no infiltration was performed. Standardized thyroidectomies were performed in the 3 groups. Pain perception was measured using VAS at 2, 4, 6, 12, and 24 hours after surgery. A comparison between the 3 groups was carried out. Results: No significant differences among the 3 groups were observed at all time points (p=0.246). Visual analog scores were significantly lower at 12 and 24 hours after operations. Conclusion: Local wound infiltration with bupivacaine 0.5% does not decrease pain perception after thyroidectomy performed under general anesthesia, and adding adrenaline does not enhance its effect.
采用视觉模拟评分法（VAS）研究甲状腺切除术后局部伤口浸润加用和不加用肾上腺素对疼痛感知的影响。方法：2015年5月至2016年6月在约旦安曼的约旦大学医院进行了一项前瞻性随机对照双盲研究。纳入89例行计划性甲状腺切除术的患者。患者随机分为3组：A组，给予0.5%布比卡因局部伤口浸润；B组，给予0.5%布比卡因加肾上腺素；C组（对照组），不进行浸润。3组均行标准化甲状腺切除术。术后2、4、6、12和24小时使用VAS测量疼痛感知。对3组进行比较。结果：在所有时间点，3组之间均未观察到显著差异（p = 0.246）。术后12和24小时视觉模拟评分显著降低。结论：全身麻醉下甲状腺切除术后，0.5%布比卡因局部伤口浸润不能降低疼痛感知，添加肾上腺素也不能增强其效果。
