Han Paul Kyu, Ma Chao, Deng Kexin, Hu Shuang, Jee Kyung-Wook, Ying Kui, Chen Yen-Lin, El Fakhri Georges
Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Biomedical Engineering, Tsinghua University, Beijing, People's Republic of China.
Magn Reson Imaging. 2018 Jan;45:18-25. doi: 10.1016/j.mri.2017.09.008. Epub 2017 Sep 14.
To develop a spectral-spatial (SPSP) excitation RF pulse for simultaneous water and lipid suppression in proton (H) magnetic resonance spectroscopic imaging (MRSI) of body extremities.
An SPSP excitation pulse is designed to excite Creatine (Cr) and Choline (Cho) metabolite signals while suppressing the overwhelming water and lipid signals. The SPSP pulse is designed using a recently proposed multidimensional Shinnar-Le Roux (SLR) RF pulse design method. A minimum-phase spectral selectivity profile is used to minimize signal loss from T decay.
The performance of the SPSP pulse is evaluated via Bloch equation simulations and phantom experiments. The feasibility of the proposed method is demonstrated using three-dimensional, short repetition-time, free induction decay-based H-MRSI in the thigh muscle at 3T.
The proposed SPSP excitation pulse is useful for simultaneous water and lipid suppression. The proposed method enables new applications of high-resolution H-MRSI in body extremities.
开发一种频谱空间（SPSP）激发射频脉冲，用于在肢体质子（H）磁共振波谱成像（MRSI）中同时抑制水和脂质信号。
设计一种SPSP激发脉冲，以激发肌酸（Cr）和胆碱（Cho）代谢物信号，同时抑制占主导地位的水和脂质信号。SPSP脉冲采用最近提出的多维辛纳 - 勒鲁（SLR）射频脉冲设计方法进行设计。使用最小相位频谱选择性轮廓来最小化T2衰减导致的信号损失。
通过布洛赫方程模拟和体模实验评估SPSP脉冲的性能。在3T下，使用基于三维、短重复时间、自由感应衰减的大腿肌肉H-MRSI证明了该方法的可行性。
所提出的SPSP激发脉冲可用于同时抑制水和脂质信号。所提出的方法使高分辨率H-MRSI在肢体中的新应用成为可能。
