Bhattacharya S K, Das N, Rao P J
Department of Pharmacology, Banaras Hindu University, Varanasi, India.
J Pharm Pharmacol. 1987 Oct;39(10):854-6. doi: 10.1111/j.2042-7158.1987.tb05134.x.
Twenty-four hours after injection of carrageenan into one hind paw, injection of the same amount into the contralateral paw produced a significantly attenuated inflammatory response. However, when the second injection was given 7 days later, the inflammation induced in the contralateral paw was comparable with the initial response to carrageenan. A time-course study of carrageenan-induced inflammation in rats showed that significant oedema persisted 24 h after carrageenan administration and complete recovery was achieved in 7 days. The attenuated inflammatory response in the contralateral paw after 24 h was antagonized by bilateral adrenalectomy and chemical sympathectomy induced by 6-hydroxydopamine. Carrageenan-induced paw oedema was also significantly less in rats with subacute inflammation induced by the croton oil granuloma pouch technique. This attenuated response was antagonized by pretreatment of the rats with metyrapone, an inhibitor of adrenocorticoid synthesis, and by 6-hydroxydopamine. It is likely that the pre-existing acute or subacute inflammation attenuates the inflammatory response of carrageenan, by acting as a stressor, inducing activation of the sympatho-adrenal system.
在向一侧后爪注射角叉菜胶24小时后，向对侧后爪注射相同剂量的角叉菜胶会产生明显减弱的炎症反应。然而，当在7天后进行第二次注射时，对侧后爪诱导的炎症与对角叉菜胶的初始反应相当。一项关于角叉菜胶诱导的大鼠炎症的时间进程研究表明，在给予角叉菜胶24小时后仍存在明显的水肿，并在7天内完全恢复。24小时后对侧后爪减弱的炎症反应可被双侧肾上腺切除术和由6-羟基多巴胺诱导的化学交感神经切除术所拮抗。在采用巴豆油肉芽肿袋技术诱导亚急性炎症的大鼠中，角叉菜胶诱导的爪部水肿也明显减轻。这种减弱的反应可被用米托坦（一种肾上腺皮质合成抑制剂）对大鼠进行预处理以及6-羟基多巴胺所拮抗。先前存在的急性或亚急性炎症可能通过作为应激源发挥作用，诱导交感-肾上腺系统激活，从而减弱角叉菜胶的炎症反应。
