Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), P.O. Box: 14155-6117, Tehran, Iran.
Osteoporosis Research Center, Endocrine Diseases and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Aging Clin Exp Res. 2018 Jun;30(6):563-571. doi: 10.1007/s40520-017-0828-2. Epub 2017 Sep 16.
BACKGROUND/OBJECTIVE: Recent studies have shown that dietary variants and genetic variants play a decisive role in the risk of developing osteoporosis. Therefore, the objective of the present study was to examine associations between dietary pattern and bone health, according to the TGF-β1 T869→C polymorphism, in postmenopausal Iranian women.
In this study, 264 postmenopausal women aged from 46 to 78 years were examined. Body composition was measured by a body composition analyzer and physical activity by the short-form physical activity questionnaire. Bone mineral density was measured by the DEXA method. Dietary patterns were determined using factor analysis on 27 foods groups, employing a valid, reliable 147-item semi-quantitative food frequency questionnaire. The dietary patterns were analyzed by the factor analysis method. Blood samples were taken for measuring blood parameters. DNA samples from participants were genotyped using the RFLP-PCR method.
Three dietary patterns were identified, namely: mediterranean diet, traditional diet, and unhealthy diet-one of which was associated with bone health. Postmenopausal women following a Mediterranean diet had lower weight and central obesity (0.05 > P). Higher adherence to a Mediterranean pattern was positively associated with Z-score L2_L4 lumbar spine (0.05 > P). TGF-β1 T869→C genotypes, after adjustment, were not directly correlated with bone mineral density and body composition (0.05 < P). Moreover, these findings demonstrated that in participants adhering to a Traditional dietary pattern, the C allele carrier group (TC and CC genotypes) had a lower L2_L4 Z-score (P = 0.05).
It seems that the mediterranean diet can be a beneficial dietary pattern in the prevention of osteoporosis and obesity in postmenopausal women. Furthermore (probably in the C allele carrier group), lower vitamin D intake, coupled with adherence to a traditional dietary pattern, reduces the deposition of TGF-beta and increases the risk of lumbar spine osteoporosis.
背景/目的：最近的研究表明，饮食变异体和遗传变异体在骨质疏松症风险中起决定性作用。因此，本研究的目的是根据 TGF-β1 T869→C 多态性，检查饮食模式与骨健康之间的关联，在绝经后伊朗女性中。
本研究共纳入 264 名年龄在 46 岁至 78 岁的绝经后女性。通过身体成分分析仪测量身体成分，通过简短形式的身体活动问卷测量身体活动。通过 DEXA 法测量骨矿物质密度。通过因子分析对 27 种食物组进行饮食模式的确定，采用有效的、可靠的 147 项半定量食物频率问卷。采用因子分析法对饮食模式进行分析。采集血样测量血液参数。采用 RFLP-PCR 法对参与者的 DNA 样本进行基因分型。
确定了三种饮食模式，即地中海饮食、传统饮食和不健康饮食，其中一种与骨健康有关。遵循地中海饮食的绝经后妇女体重和中心性肥胖较低（0.05>P）。较高的地中海饮食模式的依从性与 L2_L4 腰椎 Z 分数呈正相关（0.05>P）。调整后，TGF-β1 T869→C 基因型与骨矿物质密度和身体成分无直接相关性（0.05<P）。此外，这些发现表明，在遵循传统饮食模式的参与者中，C 等位基因携带者组（TC 和 CC 基因型）的 L2_L4 Z 分数较低（P=0.05）。
地中海饮食模式似乎可以成为绝经后妇女预防骨质疏松症和肥胖的有益饮食模式。此外（可能在 C 等位基因携带者组中），维生素 D 摄入减少，加上遵循传统饮食模式，会减少 TGF-β 的沉积，增加腰椎骨质疏松症的风险。
Zotero 插件