Moradi Sajjad, Khorrami-Nezhad Leila, Maghbooli Zhila, Hosseini Banafshe, Keshavarz Seyed Ali, Mirzaei Khadijeh
Osteoporosis Research Center, Endocrine Diseases and Metabolism Research Institute, Tehran University of Medical Sciences (TUMS).
Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS).
J Nutr Sci Vitaminol (Tokyo). 2017;63(4):228-236. doi: 10.3177/jnsv.63.228.
Osteoporosis and fragility fractures have been regarded as important public health concerns. We investigated their possible association with vitamin D receptor (VDR) FOK1 polymorphisms (rs10735810) and dietary parameters such as calcium and vitamin D intake. A total of 264 Iranian obese women (BMI>30 kg/m) were categorized based on the FOK1 genotype and divided into two groups: group one with the FF genotype (n=184) and the f allele carrier group with the Ff or ff genotype (n=80). The body composition, dietary intake and bone mineral density were assessed for all cases. The frequency of the F and f alleles for FOK1 in the study were 71.5% and 28.5%, respectively. Women with the f allele had a higher BMI (p=0.05), as well as parathyroid hormone (PTH) and tumor necrosis factor alpha (TNF-α) concentration (p=0.05, p=0.01, respectively). Participants with calcium intakes of more than 1,000 mg/d and the ff genotype had a higher L2_L4 Z-score. Moreover, women with vitamin D intakes of less than 600 IU/d and the ff genotype had a higher total T-score and total Z-score. Although women whose dietary intake of vitamin D was higher than the recommended dietary allowance (RDA>600 IU/d) and had the FF genotype had a higher total T-score and total Z-score, as well. Our findings suggest that interactions between FOK1 polymorphisms in Iranian obese women and dietary intake of calcium and vitamin D may play a decisive role in bone mineral density and osteoporosis among these women.
骨质疏松症和脆性骨折一直被视为重要的公共卫生问题。我们调查了它们与维生素D受体（VDR）FOK1基因多态性（rs10735810）以及钙和维生素D摄入量等饮食参数之间的可能关联。总共264名伊朗肥胖女性（BMI>30 kg/m）根据FOK1基因型进行分类，并分为两组：FF基因型组（n = 184）和Ff或ff基因型的f等位基因携带者组（n = 80）。对所有病例进行了身体成分、饮食摄入量和骨密度评估。研究中FOK1的F和f等位基因频率分别为71.5%和28.5%。携带f等位基因的女性BMI较高（p = 0.05），甲状旁腺激素（PTH）和肿瘤坏死因子α（TNF-α）浓度也较高（分别为p = 0.05，p = 0.01）。钙摄入量超过1000 mg/d且为ff基因型的参与者L2_L4 Z评分较高。此外，维生素D摄入量低于600 IU/d且为ff基因型的女性总T评分和总Z评分较高。尽管饮食中维生素D摄入量高于推荐膳食摄入量（RDA>600 IU/d）且为FF基因型的女性总T评分和总Z评分也较高。我们的研究结果表明，伊朗肥胖女性中FOK1基因多态性与钙和维生素D的饮食摄入量之间的相互作用可能在这些女性的骨密度和骨质疏松症中起决定性作用。
