Dai Jun-Xi, Ma Yan-Bin, Le Nan-Yang, Cao Jun, Wang Yang
a Department of Neurosurgery, Shanghai Ninth People's Hospital , Shanghai Jiao Tong University School of Medicine , Shanghai , China.
b Department of Emergency , Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine , Shanghai , China.
Int J Neurosci. 2018 Mar;128(3):243-254. doi: 10.1080/00207454.2017.1380008. Epub 2017 Oct 3.
Purpose/Aim: Animal models of traumatic brain injury (TBI) provide powerful tools to study TBI in a controlled, rigorous and cost-efficient manner. The mostly used animals in TBI studies so far are rodents. However, compared with rodents, large animals (e.g. swine, rabbit, sheep, ferret, etc.) show great advantages in modeling TBI due to the similarity of their brains to human brain. The aim of our review was to summarize the development and progress of common large animal TBI models in past 30 years.
Mixed published articles and books associated with large animal models of TBI were researched and summarized.
We majorly sumed up current common large animal models of TBI, including discussion on the available research methodologies in previous studies, several potential therapies in large animal trials of TBI as well as advantages and disadvantages of these models.
Large animal models of TBI play crucial role in determining the underlying mechanisms and screening putative therapeutic targets of TBI.
目的/目标：创伤性脑损伤（TBI）动物模型为以可控、严谨且经济高效的方式研究TBI提供了强大工具。迄今为止，TBI研究中最常用的动物是啮齿动物。然而，与啮齿动物相比，大型动物（如猪、兔、羊、雪貂等）因其大脑与人类大脑的相似性，在TBI建模方面具有很大优势。我们综述的目的是总结过去30年中常见大型动物TBI模型的发展和进展。
对与大型动物TBI模型相关的已发表文章和书籍进行了研究和总结。
我们主要总结了当前常见的大型动物TBI模型，包括对先前研究中可用研究方法的讨论、TBI大型动物试验中的几种潜在疗法以及这些模型的优缺点。
TBI大型动物模型在确定TBI的潜在机制和筛选假定治疗靶点方面发挥着关键作用。
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