Yang Luyao, Chen Pengyu, Wen Xiaofei, Zhao Qingliang
School of Pen-Tung Sah Institute of Micro-Nano Science and Technology, State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Center for Molecular Imaging and Translational Medicine, Department of Vascular & Tumor Interventional Radiology, The First Affiliated Hospital of Xiamen University, School of Medicine, School of Public Health, Xiamen University, Xiamen 361102, China.
Theranostics. 2025 Jan 1;15(1):122-140. doi: 10.7150/thno.97192. eCollection 2025.
Brain diseases are a leading cause of disability and death worldwide. Early detection can lead to earlier intervention and better outcomes for patients. In recent years, optical coherence tomography (OCT) and OCT angiography (OCTA) imaging have been widely used in stroke, traumatic brain injury (TBI), and brain cancer due to their advantages of , unlabeled, and high-resolution 3D microvessel imaging at the capillary resolution level. This review summarizes recent advances and challenges in living brain imaging using OCT/OCTA, including technique modality, types of diseases, and theoretical approach. Although there may still be many limitations, with the development of lasers and the advances in artificial intelligence are expected to enable accurate detection of deep cerebral hemodynamics and guide intraoperative tumor resection in the future.
脑部疾病是全球致残和致死的主要原因。早期检测能够为患者带来更早的干预措施并产生更好的治疗效果。近年来，光学相干断层扫描（OCT）和OCT血管造影（OCTA）成像因其具有无标记、高分辨率以及能在毛细血管分辨率水平进行三维微血管成像等优势，已在中风、创伤性脑损伤（TBI）和脑癌中得到广泛应用。本综述总结了使用OCT/OCTA进行活体脑成像的最新进展和挑战，包括技术模式、疾病类型和理论方法。尽管可能仍存在许多局限性，但随着激光技术的发展和人工智能的进步，有望在未来实现对深部脑血流动力学的准确检测并指导术中肿瘤切除。
