Ørntoft Nikolaj Worm, Thomsen Karen Louise, Dam Gitte, Aagaard Niels Kristian, Grønbæk Henning
Ugeskr Laeger. 2017 Sep 18;179(38).
Acute-on-chronic liver failure (ACLF) is a clinical syndrome characterized by acute decompensation of liver cirrhosis, organ failure and high short-term mortality (20-80% at one month). The main precipitants are infections and excessive alcohol intake, and the mechanistic features include a high level of systemic inflammation, macrophage activation and liver injury. The severity of ACLF is graded according to the number and extent of organ failures. Prognostic scores help predict mortality and support decisions on intensive treatment or futility.
慢加急性肝衰竭（ACLF）是一种临床综合征，其特征为肝硬化急性失代偿、器官衰竭和短期高死亡率（1个月时为20%-80%）。主要诱因是感染和过量饮酒，其机制特点包括全身性炎症水平高、巨噬细胞活化和肝损伤。ACLF的严重程度根据器官衰竭的数量和程度进行分级。预后评分有助于预测死亡率，并为强化治疗或放弃治疗的决策提供依据。
