Department of Epidemiology, University of Maryland School of Medicine, 10 S. Pine Street, MSTF 334F, Baltimore, MD 21201, USA.
Cancer Center Department: Epidemiology Program, University of Hawaii Manoa, 701 Ilalo St. Rm 525, Honolulu, HI 96813, USA.
Harmful Algae. 2016 Jul;57(Pt B):9-19. doi: 10.1016/j.hal.2016.03.010. Epub 2016 Aug 30.
The CoASTAL cohort represents the first community cohort assembled to study a HAB-related illness. It is comprised of three Native American tribes in the Pacific NW for the purpose of studying the health impacts of chronic, low level domoic acid (DA) exposure through razor clam consumption. This cohort is at risk of DA toxicity by virtue of their geographic location (access to beaches with a history of elevated DA levels in razor clams) and the cultural and traditional significance of razor clams in their diet. In this prospective, longitudinal study, Wave 1 of the cohort was comprised of 678 members across the human lifespan, with both sexes represented within child, adult, and geriatric age groups. All participants were followed annually with standard measures of medical and social history; neuropsychological functions, psychological status, and dietary exposure. DA concentrations were measured at both public and reservation beaches where razor clams are acquired. Multiple metrics were piloted to further determine exposure. Baseline data indicated that all cognitive and psychological functions were within normal limits. In addition, there was considerable variability in razor clam exposure. Therefore, the CoASTAL cohort offers a unique opportunity to investigate the potential health effects of chronic, low level exposure to DA over time.
CoASTAL 队列代表了第一个为研究与赤潮相关的疾病而组建的社区队列。该队列由太平洋西北地区的三个美国原住民部落组成，目的是通过食用贻贝研究慢性、低水平的软骨藻酸（DA）暴露对健康的影响。由于地理位置的原因（靠近历史上贻贝中 DA 水平升高的海滩）以及贻贝在他们饮食中的文化和传统意义，该队列存在 DA 毒性的风险。在这项前瞻性、纵向研究中，队列的第 1 波由跨越人类生命周期的 678 名成员组成，包括儿童、成人和老年组的男女成员。所有参与者每年都接受标准的医疗和社会史、神经心理功能、心理状况和饮食暴露监测。在公众和保留地海滩上都测量了贻贝中的 DA 浓度，这些海滩是获取贻贝的地方。为了进一步确定暴露情况，还进行了多项指标的试点研究。基线数据表明，所有认知和心理功能均在正常范围内。此外，贻贝的暴露情况存在很大差异。因此，CoASTAL 队列提供了一个独特的机会，可以研究慢性、低水平暴露于 DA 对健康的潜在影响。
