McNicholas Colleen P, Klugman Jessica B, Zhao Qiuhong, Peipert Jeffrey F
Division of Clinical Research, Department of Obstetrics and Gynecology, Washington University in St Louis School of Medicine, St Louis, MO.
Division of Clinical Research, Department of Obstetrics and Gynecology, Washington University in St Louis School of Medicine, St Louis, MO.
Am J Obstet Gynecol. 2017 Dec;217(6):672.e1-672.e6. doi: 10.1016/j.ajog.2017.09.009. Epub 2017 Sep 14.
Use of more effective contraception may lead to less condom use and increased incidence of sexually transmitted infection.
The objective of this study was to compare changes in condom use and incidence of sexually transmitted infection acquisition among new initiators of long-acting reversible contraceptives to those initiating non-long-acting reversible contraceptive methods.
This is a secondary analysis of the Contraceptive CHOICE Project. We included 2 sample populations of 12-month continuous contraceptive users. The first included users with complete condom data (baseline, and 3, 6, and 12 months) (long-acting reversible contraceptive users: N = 2371; other methods: N = 575). The second included users with 12-month sexually transmitted infection data (long-acting reversible contraceptive users: N = 2102; other methods: N = 592). Self-reported condom use was assessed at baseline and at 3, 6, and 12 months following enrollment. Changes in condom use and incident sexually transmitted infection rates were compared using χ tests. Risk factors for sexually transmitted infection acquisition were identified using multivariable logistic regression.
Few participants in either group reported consistent condom use across all survey time points and with all partners (long-acting reversible contraceptive users: 5.2%; other methods: 11.3%; P < .001). There was no difference in change of condom use at 3, 6, and 12 months compared to baseline condom use regardless of method type (P = .65). A total of 94 incident sexually transmitted infections were documented, with long-acting reversible contraceptive users accounting for a higher proportion (3.9% vs 2.0%; P = .03). Initiation of a long-acting reversible contraceptive method was associated with increased sexually transmitted infection incidence (odds ratio, 2.0; 95% confidence ratio, 1.07-3.72).
Long-acting reversible contraceptive initiators reported lower rates of consistent condom use, but did not demonstrate a change in condom use when compared to preinitiation behaviors. Long-acting reversible contraceptive users were more likely to acquire a sexually transmitted infection in the 12 months following initiation.
使用更有效的避孕方法可能导致避孕套使用减少以及性传播感染发生率增加。
本研究的目的是比较长效可逆避孕方法新使用者与开始使用非长效可逆避孕方法者在避孕套使用情况和性传播感染发生率方面的变化。
这是对避孕选择项目的二次分析。我们纳入了两组连续使用避孕方法12个月的样本人群。第一组包括有完整避孕套使用数据(基线、3个月、6个月和12个月)的使用者(长效可逆避孕方法使用者:N = 2371;其他方法使用者:N = 575)。第二组包括有12个月性传播感染数据的使用者(长效可逆避孕方法使用者:N = 2102;其他方法使用者:N = 592)。在基线以及入组后的3个月、6个月和12个月评估自我报告的避孕套使用情况。使用χ检验比较避孕套使用情况的变化和性传播感染发病率。使用多变量逻辑回归确定性传播感染的危险因素。
两组中很少有参与者报告在所有调查时间点对所有性伴侣都持续使用避孕套(长效可逆避孕方法使用者:5.2%;其他方法使用者:11.3%;P <.001)。无论方法类型如何,与基线避孕套使用情况相比,3个月、6个月和12个月时避孕套使用情况的变化没有差异(P =.65)。共记录了94例新发的性传播感染,长效可逆避孕方法使用者占比更高(3.9%对2.0%;P =.03)。开始使用长效可逆避孕方法与性传播感染发病率增加相关(比值比,2.0;95%置信比,1.07 - 3.72)。
长效可逆避孕方法使用者报告的持续使用避孕套比例较低,但与开始使用前的行为相比,避孕套使用情况没有变化。长效可逆避孕方法使用者在开始使用后的12个月内更有可能感染性传播感染。