i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugal; Instituto de Ciências Biomédicas Abel Salazar, University of Porto, Porto, Portugal.
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugal.
Drug Discov Today. 2018 May;23(5):944-959. doi: 10.1016/j.drudis.2017.08.011. Epub 2017 Sep 15.
The intracellular delivery of nanomaterials and drugs has been attracting increasing research interest, mainly because of their important effects and functions in several organelles. Targeting specific organelles can help treat or decrease the symptoms of diabetes, cancer, infectious, and autoimmune diseases. Tuning biological and chemical properties enables the creation of functionalized nanomaterials with enhanced intracellular uptake, ability to escape premature lysosome degradation, and to reach a specific target. Here, we provide an update of recent advances in the intracellular delivery mechanisms that could help drugs reach their target more efficiently.
纳米材料和药物的细胞内递呈一直受到越来越多的研究关注，主要是因为它们在几个细胞器中具有重要的作用和功能。靶向特定的细胞器有助于治疗或减轻糖尿病、癌症、传染病和自身免疫性疾病的症状。调整生物和化学性质可以使功能化纳米材料的创建具有增强的细胞内摄取能力、逃避过早的溶酶体降解的能力，并达到特定的靶标。在这里，我们提供了对有助于药物更有效地到达靶标的细胞内递呈机制的最新进展的更新。
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