Pediatric Environmental Health Center, Boston, Mass; Region 1 New England Pediatric Environmental Health Specialty Unit, Boston, Mass; Harvard Medical School, Boston, Mass.
Division of Adolescent Medicine, Boston Children's Hospital, Boston, Mass; Department of Neurology, Boston Children's Hospital, Boston, Mass; Harvard Medical School, Boston, Mass.
Acad Pediatr. 2018 Mar;18(2):161-165. doi: 10.1016/j.acap.2017.09.003. Epub 2017 Sep 14.
To evaluate relationships between whole blood (B-Al) and hair aluminum (H-Al) levels in healthy infants and their immunization history and development.
We conducted a cross-sectional study of 9- to 13-month-old children recruited from an urban primary care center, excluding those with a history of renal disease or receipt of either aluminum-containing pharmaceuticals or parenteral nutrition. Aluminum levels were measured using inductively coupled plasma-mass spectrometry. Correlation with Bayley Scales of Infant and Toddler Development, Third Edition (BSID) and vaccine-related aluminum load was assessed via linear regression models.
The median age of 85 participants was 287 days. B-Al (median, 15.4 ng/mL; range, 0.9-952 ng/mL) and H-Al (median 42,542 ng/g; range, 2758-211,690 ng/g) were weakly correlated (Spearman ρ = 0.26; P = .03). There was no significant correlation between B-Al or H-Al and estimated aluminum load from vaccines. B-Al was not correlated with BSID composite or subscale scores. Although H-Al was not correlated with BSID scores in models including all data (n = 85), it was inversely correlated with motor composite (P < .02; Wald = 5.88) and the gross motor subscale (P = .04; Wald = 4.38) in models that excluded an extreme outlying H-Al value.
Infant B-Al and H-Al varied considerably but did not correlate with their immunization history. Likewise, there was no correlation between B-Al and infant development or between H-Al and language or cognitive development. An inverse correlation between H-Al and BSID motor scores deserves further investigation.
评估健康婴儿全血（B-Al）和毛发铝（H-Al）水平与其免疫接种史和发育之间的关系。
我们对来自城市初级保健中心的 9 至 13 个月大的儿童进行了横断面研究，排除了有肾脏疾病史或接受含铝药物或肠外营养的儿童。使用电感耦合等离子体质谱法测量铝含量。通过线性回归模型评估与贝利婴幼儿发育量表第三版（BSID）和疫苗相关的铝负荷的相关性。
85 名参与者的中位年龄为 287 天。B-Al（中位数，15.4ng/mL；范围，0.9-952ng/mL）和 H-Al（中位数 42542ng/g；范围，2758-211690ng/g）呈弱相关（Spearman ρ=0.26；P=0.03）。B-Al 或 H-Al 与疫苗估计的铝负荷之间无显著相关性。B-Al 与 BSID 综合或子量表评分均无相关性。尽管 H-Al 与包括所有数据的 BSID 评分模型（n=85）不相关，但在排除一个极端异常 H-Al 值的模型中，H-Al 与运动综合评分（P<0.02；Wald=5.88）和大运动子量表评分（P=0.04；Wald=4.38）呈负相关。
婴儿 B-Al 和 H-Al 变化较大，但与免疫接种史无关。同样，B-Al 与婴儿发育之间或 H-Al 与语言或认知发育之间也无相关性。H-Al 与 BSID 运动评分之间的负相关值得进一步研究。
