Nassar Mogahid Yahi'a, Al-Shamahy Hassan Abdulwahab, Al-Samawi Abdullah Saleh, Abu Asba Nagieb Waza'a, El-Nono Ibrahiem Husain, Masood Haitham Abdulwahab
Department of Clinical Pathology, Faculty of Medicine and Health Sciences, University of Science and Technology, Sana'a, Yemen.
Iran J Immunol. 2017 Sep;14(3):240-249.
Human leukocyte antigens (HLAs) are found to be significant genetic factors concerning the susceptibility of an individual to certain diseases.
To determine the association between variants of class I (A and B) and class II (DRB1) HLA alleles and chronic renal failure (CRF), compared with healthy controls, in Yemen.
A case-control study in the Urology and Nephrology Center at Al-Thawra University Hospital in Sana'a, Yemen was carried out between January 2013 and December 2015 and included 187 CRF patients, and 194 healthy controls visiting the same center for kidney donation. All CRF patients in the study were on haemodialysis. The control group was confirmed to be healthy following a clinical examination by specialist physicians. Among both patients and controls, HLA class I (A and B) and class II (DRB1) HLA typing was carried out by Sequence Specific Primers (SSP) polymerase chain reaction (PCR).
There was a significant protective function for HLA-A30 gene (CRF 9.1% vs. con 16%, p=0.045) against CRF development. There was a high frequency of HLA-A02, HLA-B51 and HLA-DRB104 alleles in both patients and controls.
No HLAs were located to have a significant association with genetic tendency to CRF in the current study population, however, certain HLA alleles, for instance in HLA-A*30, could be considered protective against CRF progress.
人类白细胞抗原（HLA）被发现是关乎个体对某些疾病易感性的重要遗传因素。
在也门，与健康对照相比，确定I类（A和B）和II类（DRB1）HLA等位基因变体与慢性肾衰竭（CRF）之间的关联。
2013年1月至2015年12月期间，在也门萨那的塔瓦拉大学医院泌尿外科和肾病中心开展了一项病例对照研究，纳入187例CRF患者以及194名因肾脏捐献前来该中心就诊的健康对照。研究中的所有CRF患者均接受血液透析。经专科医生临床检查，确认对照组健康。在患者和对照中，均通过序列特异性引物（SSP）聚合酶链反应（PCR）进行HLA I类（A和B）和II类（DRB1）HLA分型。
HLA - A30基因对CRF的发生具有显著的保护作用（CRF组为9.1%，对照组为16%，p = 0.045）。患者和对照组中HLA - A02、HLA - B51和HLA - DRB04等位基因的频率均较高。
在当前研究人群中，未发现HLA与CRF的遗传倾向存在显著关联，然而，某些HLA等位基因，例如HLA - A*30，可被认为对CRF进展具有保护作用。
