也门精神分裂症患者中人类白细胞抗原-DR/DQ多态性与精神分裂症的潜在关联

Potential Involvement of Human Leukocyte Antigen-DR/DQ Polymorphisms with Schizophrenia Among Patients with Schizophrenia in Yemen.

作者信息

Al-Shamahy Hassan Abdulwahab, Abdo Hassan Sami Mohammed

机构信息

Medical Microbiology and Clinical Immunology Department, Faculty of Medicine and Health Sciences, Sana'a University, Sana'a, Yemen.

Medical Microbiology Department, Faculty of Medicine, Genius University for Sciences and Technology, Dhamar, Yemen.

出版信息

Oman Med J. 2024 Jan 31;39(1):e590. doi: 10.5001/omj.2024.46. eCollection 2024 Jan.

DOI:10.5001/omj.2024.46

PMID:39006310

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11246548/

Abstract

OBJECTIVES

To evaluate the hypothesis that human leukocyte antigens (HLAs) confer susceptibility to schizophrenic disorders, by assessing their contribution to the risk of schizophrenia in a Yemeni population.

METHODS

The researchers approached patients who had been diagnosed with schizophrenia at Al-Amal Hospital for Psychiatric Diseases, Sana'a. Controls were drawn randomly from the general population. The HLA class II alleles of the participants were examined. The genotypes of the HLA-DQB1 and HLA-DRB1 alleles were determined by polymerase chain reaction using sequence-specific primers.

RESULTS

The subjects comprised 110 patients with schizophrenia, matched by an equal number of controls. The prevalence of HLA-DRB104 was significantly higher among patients than among controls (7.3% vs. 0.0%; 0.003), as was HLA-DRB107 (62.7% vs. 17.3%, odds ratio (OR) = 8.1, 95% CI: 4.3-15.1; < 0.001). HLA-DRBI14 was significantly less prevalent among patients (0.9% vs. 11.8%, OR = 0.06, 95% CI: 0.01-0.50, χ = 10.9; < 0.001). HLA-DQB107 was the most common allele discovered in schizophrenia patients and was found to have a much higher incidence in patients than the control group (22.7% vs. 4.5%, OR = 6.2, 95%CI: 2.3-16.8, χ = 15.4; < 0.001).

CONCLUSIONS

The HLA-DQB1 and HLA-DRB1 gene loci are linked to schizophrenia in the Yemeni population, according to the current study's evidence.

摘要

目的

通过评估人类白细胞抗原（HLA）对也门人群精神分裂症风险的影响，来验证HLA是否会使人易患精神分裂症这一假设。

方法

研究人员接触了在萨那的阿玛尔精神疾病医院被诊断为精神分裂症的患者。对照组从普通人群中随机抽取。检测了参与者的HLA II类等位基因。采用序列特异性引物的聚合酶链反应确定HLA - DQB1和HLA - DRB1等位基因的基因型。

结果

研究对象包括110例精神分裂症患者，匹配了同等数量的对照组。患者中HLA - DRB104的患病率显著高于对照组（7.3%对0.0%；P = 0.003），HLA - DRB107也是如此（62.7%对17.3%，优势比（OR）= 8.1，95%置信区间：4.3 - 15.1；P < 0.001）。患者中HLA - DRB114的患病率显著更低（0.9%对11.8%，OR = 0.06，95%置信区间：0.01 - 0.50，χ² = 10.9；P < 0.001）。HLA - DQB107是在精神分裂症患者中发现的最常见等位基因，且在患者中的发生率远高于对照组（22.7%对4.5%，OR = 6.2，95%置信区间：2.3 - 16.8，χ² = 15.4；P < 0.001）。