生殖系基因编辑的伦理问题。
The Ethics of Germline Gene Editing.
作者信息
Gyngell Christopher, Douglas Thomas, Savulescu Julian
机构信息
Oxford Uehiro Centre for Practical Ethics University of Oxford Littlegate House St Ebbes Street Oxford OX1 1PT UK.
Oxford Uehiro Centre for Practical Ethics and Mansfield CollegeUniversity of Oxford.
出版信息
J Appl Philos. 2017 Aug;34(4):498-513. doi: 10.1111/japp.12249. Epub 2016 Nov 9.
Germline Gene Editing (GGE) has enormous potential both as a research tool and a therapeutic intervention. While other types of gene editing are relatively uncontroversial, GGE has been strongly resisted. In this article, we analyse the ethical arguments for and against pursuing GGE by allowing and funding its development. We argue there is a strong case for pursuing GGE for the prevention of disease. We then examine objections that have been raised against pursuing GGE and argue that these fail. We conclude that the moral case in favour of pursuing GGE is stronger than the case against. This suggests that pursuing GGE is morally permissible and indeed morally desirable.
种系基因编辑（GGE）作为一种研究工具和治疗手段具有巨大潜力。虽然其他类型的基因编辑相对没有争议，但GGE却遭到了强烈抵制。在本文中，我们分析了支持和反对通过允许并资助其发展来推进GGE的伦理观点。我们认为，有充分理由推进GGE以预防疾病。然后，我们审视了针对推进GGE所提出的反对意见，并认为这些反对意见不成立。我们得出结论，支持推进GGE的道德理由比反对的理由更充分。这表明推进GGE在道德上是允许的，甚至在道德上是可取的。
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