Hu Runlei, Zhang Xiaodong, Liu Xuan, Xu Bo, Yang Hongsheng, Xia Qisheng, Li Liya, Chen Chunling, Tang Jintian
Department of Thoracic Surgery, Hangzhou First People's Hospital, Hangzhou, Zhejiang Province, China Institute of Medical Physics and Engineering, Tsinghua University, Beijing, China Department of Biochemistry and Molecular Biology, China-Japan Friendship Institute of Clinical Medical Sciences, Beijing, China Department of Thoracic Surgery, First Affiliated Hospital of Kunming Medical College, Kunming, Yunnan Province, China.
Thorac Cancer. 2012 Feb;3(1):34-39. doi: 10.1111/j.1759-7714.2011.00075.x.
PURPOSE: The aim of this study was to investigate the effect of a higher temperature on the efficacy of magnetic fluid hyperthermia for Lewis lung cancer in a mouse model. MATERIALS AND METHODS: Magnetic fluids were prepared in vitro and directly injected into tumors. Twenty-four hours later, the mice were subjected to an alternating magnetic field. The temperature in the tumor was increased to 46.0°C, higher than the usual temperature used in hyperthermia therapy. The higher temperature was maintained for 30 min with a stable strength of magnetic field. RESULTS: Magnetic fluid hyperthermia with a higher temperature significantly inhibited the growth of the tumors (P < 0.05). The tumors completely regressed in four out of 12 mice. Histological analysis demonstrated that the tumor cells underwent apoptosis and necrosis, and the cells were arrested at the G1/G0 phase of the cell cycle. The lifespan of the treated animals also increased significantly (P < 0.05). CONCLUSIONS: Magnetic fluid hyperthermia with a higher temperature could improve the efficacy of this therapy on lung cancer.
目的：本研究旨在探讨较高温度对小鼠模型中磁性流体热疗治疗Lewis肺癌疗效的影响。 材料与方法：体外制备磁性流体并直接注射到肿瘤中。24小时后，对小鼠施加交变磁场。将肿瘤温度升至46.0°C，高于热疗常用温度。在磁场强度稳定的情况下，较高温度维持30分钟。 结果：较高温度的磁性流体热疗显著抑制了肿瘤生长（P < 0.05）。12只小鼠中有4只肿瘤完全消退。组织学分析表明，肿瘤细胞发生凋亡和坏死，细胞停滞在细胞周期的G1/G0期。接受治疗的动物寿命也显著延长（P < 0.05）。 结论：较高温度的磁性流体热疗可提高该疗法对肺癌的疗效。
Int J Hyperthermia. 2009-2
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