• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

具有生物相容性γ-环糊精修饰的 FeO 纳米粒子用于超顺磁热疗的癌症治疗的最大比损耗功率研究。

Study on Maximum Specific Loss Power in FeO Nanoparticles Decorated with Biocompatible Gamma-Cyclodextrins for Cancer Therapy with Superparamagnetic Hyperthermia.

机构信息

Department of Physics, Faculty of Physics, West University of Timişoara, 300223 Timişoara, Romania.

Department of Plastic and Reconstructive Surgery, Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy of Timişoara, 300041 Timişoara, Romania.

出版信息

Int J Mol Sci. 2021 Sep 17;22(18):10071. doi: 10.3390/ijms221810071.

DOI:10.3390/ijms221810071
PMID:34576233
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8470897/
Abstract

Different chemical agents are used for the biocompatibility and/or functionality of the nanoparticles used in magnetic hyperthermia to reduce or even eliminate cellular toxicity and to limit the interaction between them (van der Waals and magnetic dipolar interactions), with highly beneficial effects on the efficiency of magnetic hyperthermia in cancer therapy. In this paper we propose an innovative strategy for the biocompatibility of these nanoparticles using gamma-cyclodextrins (γ-CDs) to decorate the surface of magnetite (FeO) nanoparticles. The influence of the biocompatible organic layer of cyclodextrins, from the surface of FeO ferrimagnetic nanoparticles, on the maximum specific loss power in superparamagnetic hyperthermia, is presented and analyzed in detail in this paper. Furthermore, our study shows the optimum conditions in which the magnetic nanoparticles covered with gamma-cyclodextrin (FeO-γ-CDs) can be utilized in superparamagnetic hyperthermia for an alternative cancer therapy with higher efficiency in destroying tumoral cells and eliminating cellular toxicity.

摘要

不同的化学试剂用于生物相容性和/或功能的磁性热疗中使用的纳米粒子，以减少甚至消除细胞毒性，并限制它们之间的相互作用（范德华力和磁偶极子相互作用），对磁性热疗在癌症治疗中的效率有很大的益处。在本文中，我们提出了一种使用γ-环糊精（γ-CDs）来修饰磁铁矿（FeO）纳米粒子表面的磁性纳米粒子的生物相容性的创新策略。本文详细介绍并分析了生物相容性有机层环糊精从铁氧体铁磁性纳米粒子表面对超顺磁热疗中最大比损耗功率的影响。此外，我们的研究表明，在超顺磁热疗中，用γ-环糊精（FeO-γ-CDs）覆盖的磁性纳米粒子可以在最佳条件下用于替代癌症治疗，以更高的效率破坏肿瘤细胞并消除细胞毒性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fdd/8470897/b10ecd11e7c5/ijms-22-10071-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fdd/8470897/8a210a1165f2/ijms-22-10071-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fdd/8470897/3948a6cde2d0/ijms-22-10071-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fdd/8470897/0ed5d2a6ed39/ijms-22-10071-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fdd/8470897/157a43a56a66/ijms-22-10071-g004a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fdd/8470897/f1a75925e128/ijms-22-10071-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fdd/8470897/b1a6f1bda939/ijms-22-10071-g006a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fdd/8470897/d56f6fcac93f/ijms-22-10071-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fdd/8470897/002946e9bcb7/ijms-22-10071-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fdd/8470897/d77ff8463799/ijms-22-10071-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fdd/8470897/e5b17be1f280/ijms-22-10071-g010a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fdd/8470897/b10ecd11e7c5/ijms-22-10071-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fdd/8470897/8a210a1165f2/ijms-22-10071-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fdd/8470897/3948a6cde2d0/ijms-22-10071-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fdd/8470897/0ed5d2a6ed39/ijms-22-10071-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fdd/8470897/157a43a56a66/ijms-22-10071-g004a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fdd/8470897/f1a75925e128/ijms-22-10071-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fdd/8470897/b1a6f1bda939/ijms-22-10071-g006a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fdd/8470897/d56f6fcac93f/ijms-22-10071-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fdd/8470897/002946e9bcb7/ijms-22-10071-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fdd/8470897/d77ff8463799/ijms-22-10071-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fdd/8470897/e5b17be1f280/ijms-22-10071-g010a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fdd/8470897/b10ecd11e7c5/ijms-22-10071-g011.jpg

相似文献

1
Study on Maximum Specific Loss Power in FeO Nanoparticles Decorated with Biocompatible Gamma-Cyclodextrins for Cancer Therapy with Superparamagnetic Hyperthermia.具有生物相容性γ-环糊精修饰的 FeO 纳米粒子用于超顺磁热疗的癌症治疗的最大比损耗功率研究。
Int J Mol Sci. 2021 Sep 17;22(18):10071. doi: 10.3390/ijms221810071.
2
Superparamagnetic Hyperthermia Study with Cobalt Ferrite Nanoparticles Covered with γ-Cyclodextrins by Computer Simulation for Application in Alternative Cancer Therapy.通过计算机模拟用 γ-环糊精包覆的钴铁氧体纳米粒子的超顺磁热疗研究，应用于癌症的替代疗法。
Int J Mol Sci. 2022 Apr 14;23(8):4350. doi: 10.3390/ijms23084350.
3
FeO-PAA-(HP-γ-CDs) Biocompatible Ferrimagnetic Nanoparticles for Increasing the Efficacy in Superparamagnetic Hyperthermia.用于提高超顺磁性热疗疗效的FeO-PAA-(HP-γ-CDs)生物相容性亚铁磁性纳米颗粒
Nanomaterials (Basel). 2022 Jul 27;12(15):2577. doi: 10.3390/nano12152577.
4
In Vitro Superparamagnetic Hyperthermia Employing Magnetite Gamma-Cyclodextrin Nanobioconjugates for Human Squamous Skin Carcinoma Therapy.体外超顺磁热疗用人血白蛋白-γ-环糊精磁纳米复合物治疗人鳞状细胞癌
Int J Mol Sci. 2024 Jul 31;25(15):8380. doi: 10.3390/ijms25158380.
5
Optimization Study on Specific Loss Power in Superparamagnetic Hyperthermia with Magnetite Nanoparticles for High Efficiency in Alternative Cancer Therapy.基于磁铁矿纳米颗粒的超顺磁性热疗中比损耗功率的优化研究，以实现替代癌症治疗的高效性
Nanomaterials (Basel). 2020 Dec 26;11(1):40. doi: 10.3390/nano11010040.
6
Physical contribution of Néel and Brown relaxation to interpreting intracellular hyperthermia characteristics using superparamagnetic nanofluids.奈耳弛豫和布朗弛豫对利用超顺磁性纳米流体解释细胞内热疗特性的物理贡献。
J Nanosci Nanotechnol. 2013 Aug;13(8):5719-25. doi: 10.1166/jnn.2013.7524.
7
Radio frequency plasma assisted surface modification of FeO nanoparticles using polyaniline/polypyrrole for bioimaging and magnetic hyperthermia applications.使用聚苯胺/聚吡咯对FeO纳米颗粒进行射频等离子体辅助表面改性，用于生物成像和磁热疗应用。
J Mater Sci Mater Med. 2021 Aug 25;32(9):108. doi: 10.1007/s10856-021-06563-1.
8
Comparative evaluation of magnetic hyperthermia performance and biocompatibility of magnetite and novel Fe-doped hardystonite nanoparticles for potential bone cancer therapy.比较研究磁铁矿和新型掺铁硬硅钙石纳米颗粒用于潜在骨癌治疗的磁热性能和生物相容性。
Mater Sci Eng C Mater Biol Appl. 2019 May;98:930-938. doi: 10.1016/j.msec.2019.01.038. Epub 2019 Jan 9.
9
One-pot preparation of hyaluronic acid-coated iron oxide nanoparticles for magnetic hyperthermia therapy and targeting CD44-overexpressing cancer cells.一锅法制备透明质酸包覆的氧化铁纳米粒子用于磁热疗和靶向 CD44 过表达的癌细胞。
Carbohydr Polym. 2020 Jun 1;237:116130. doi: 10.1016/j.carbpol.2020.116130. Epub 2020 Mar 6.
10
Therapeutic evaluation of magnetic hyperthermia using Fe3O4-aminosilane-coated iron oxide nanoparticles in glioblastoma animal model.在胶质母细胞瘤动物模型中使用Fe3O4-氨基硅烷包覆的氧化铁纳米颗粒进行磁热疗的治疗评估
Einstein (Sao Paulo). 2019 Aug 1;17(4):eAO4786. doi: 10.31744/einstein_journal/2019AO4786.

引用本文的文献

1
Special Issue on Nanoparticles in Nanobiotechnology and Nanomedicine.纳米生物技术与纳米医学中的纳米颗粒特刊。
Int J Mol Sci. 2024 Dec 31;26(1):267. doi: 10.3390/ijms26010267.
2
An Overview of Polymeric Nanoplatforms to Deliver Veterinary Antimicrobials.用于递送兽用抗菌剂的聚合物纳米平台概述
Nanomaterials (Basel). 2024 Feb 9;14(4):341. doi: 10.3390/nano14040341.
3
The Role of Cyclodextrin in the Construction of Nanoplatforms: From Structure, Function and Application Perspectives.环糊精在纳米平台构建中的作用：从结构、功能及应用角度探讨

本文引用的文献

1
Effective Cancer Theranostics with Polymer Encapsulated Superparamagnetic Nanoparticles: Combined Effects of Magnetic Hyperthermia and Controlled Drug Release.聚合物包裹超顺磁性纳米粒子用于有效的癌症诊疗：磁热疗与可控药物释放的联合效应
ACS Biomater Sci Eng. 2017 Jul 10;3(7):1332-1340. doi: 10.1021/acsbiomaterials.6b00420. Epub 2016 Dec 12.
2
Optimization Study on Specific Loss Power in Superparamagnetic Hyperthermia with Magnetite Nanoparticles for High Efficiency in Alternative Cancer Therapy.基于磁铁矿纳米颗粒的超顺磁性热疗中比损耗功率的优化研究，以实现替代癌症治疗的高效性
Nanomaterials (Basel). 2020 Dec 26;11(1):40. doi: 10.3390/nano11010040.
3
Pharmaceutics. 2023 May 19;15(5):1536. doi: 10.3390/pharmaceutics15051536.
4
Electrospun Magnetic Nanofiber Mats for Magnetic Hyperthermia in Cancer Treatment Applications-Technology, Mechanism, and Materials.用于癌症治疗应用中磁热疗的电纺磁性纳米纤维垫——技术、机制与材料
Polymers (Basel). 2023 Apr 15;15(8):1902. doi: 10.3390/polym15081902.
5
High Efficacy on the Death of Breast Cancer Cells Using SPMHT with Magnetite Cyclodextrins Nanobioconjugates.使用含磁铁矿环糊精纳米生物结合物的SPMHT对乳腺癌细胞死亡具有高效性。
Pharmaceutics. 2023 Apr 4;15(4):1145. doi: 10.3390/pharmaceutics15041145.
6
Nanomaterials in Cancer Diagnosis and Therapy.用于癌症诊断与治疗的纳米材料
Int J Mol Sci. 2022 Nov 9;23(22):13770. doi: 10.3390/ijms232213770.
7
Magneto-Mechanical Approach in Biomedicine: Benefits, Challenges, and Future Perspectives.磁机械方法在生物医学中的应用：益处、挑战和未来展望。
Int J Mol Sci. 2022 Sep 22;23(19):11134. doi: 10.3390/ijms231911134.
8
FeO-PAA-(HP-γ-CDs) Biocompatible Ferrimagnetic Nanoparticles for Increasing the Efficacy in Superparamagnetic Hyperthermia.用于提高超顺磁性热疗疗效的FeO-PAA-(HP-γ-CDs)生物相容性亚铁磁性纳米颗粒
Nanomaterials (Basel). 2022 Jul 27;12(15):2577. doi: 10.3390/nano12152577.
9
Superparamagnetic Hyperthermia Study with Cobalt Ferrite Nanoparticles Covered with γ-Cyclodextrins by Computer Simulation for Application in Alternative Cancer Therapy.通过计算机模拟用 γ-环糊精包覆的钴铁氧体纳米粒子的超顺磁热疗研究，应用于癌症的替代疗法。
Int J Mol Sci. 2022 Apr 14;23(8):4350. doi: 10.3390/ijms23084350.
Therapeutic Efficiency of Multiple Applications of Magnetic Hyperthermia Technique in Glioblastoma Using Aminosilane Coated Iron Oxide Nanoparticles: In Vitro and In Vivo Study.
采用氨基硅烷修饰的氧化铁纳米粒子的多次磁热疗技术治疗脑胶质母细胞瘤的疗效：体外与体内研究。
Int J Mol Sci. 2020 Jan 31;21(3):958. doi: 10.3390/ijms21030958.
4
Photoacoustic-Enabled Self-Guidance in Magnetic-Hyperthermia Fe@Fe O Nanoparticles for Theranostics In Vivo.光声引导下的 Fe@Fe2O3 纳米颗粒用于体内治疗学的磁热疗。
Adv Healthc Mater. 2018 May;7(9):e1701201. doi: 10.1002/adhm.201701201. Epub 2018 Jan 22.
5
Higher temperature improves the efficacy of magnetic fluid hyperthermia for Lewis lung cancer in a mouse model.较高温度可提高磁性流体热疗对小鼠模型中Lewis肺癌的疗效。
Thorac Cancer. 2012 Feb;3(1):34-39. doi: 10.1111/j.1759-7714.2011.00075.x.
6
Synthesis of Ferromagnetic Fe0.6 Mn0.4 O Nanoflowers as a New Class of Magnetic Theranostic Platform for In Vivo T1 -T2 Dual-Mode Magnetic Resonance Imaging and Magnetic Hyperthermia Therapy.合成具有铁磁性的 Fe0.6 Mn0.4 O 纳米花作为一种新型的体内 T1-T2 双模态磁共振成像和磁热疗的磁性治疗一体化平台。
Adv Healthc Mater. 2016 Aug;5(16):2092-104. doi: 10.1002/adhm.201600357. Epub 2016 Jun 14.
7
Local hyperthermia combined with radiotherapy and-/or chemotherapy: recent advances and promises for the future.局部热疗联合放化疗：现状与未来展望。
Cancer Treat Rev. 2015 Nov;41(9):742-53. doi: 10.1016/j.ctrv.2015.05.009. Epub 2015 May 27.
8
Combining magnetic hyperthermia and photodynamic therapy for tumor ablation with photoresponsive magnetic liposomes.用光响应磁性脂质体将磁热疗与光动力疗法相结合用于肿瘤消融。
ACS Nano. 2015 Mar 24;9(3):2904-16. doi: 10.1021/nn506949t. Epub 2015 Feb 27.
9
Antitumor immunity by magnetic nanoparticle-mediated hyperthermia.磁性纳米颗粒介导的热疗产生的抗肿瘤免疫
Nanomedicine (Lond). 2014 Aug;9(11):1715-26. doi: 10.2217/nnm.14.106.
10
Use of bacterial magnetosomes in the magnetic hyperthermia treatment of tumours: a review.细菌磁小体在肿瘤磁热疗中的应用：综述。
Int J Hyperthermia. 2013 Dec;29(8):801-9. doi: 10.3109/02656736.2013.821527. Epub 2013 Sep 11.