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具有生物相容性γ-环糊精修饰的 FeO 纳米粒子用于超顺磁热疗的癌症治疗的最大比损耗功率研究。

Study on Maximum Specific Loss Power in FeO Nanoparticles Decorated with Biocompatible Gamma-Cyclodextrins for Cancer Therapy with Superparamagnetic Hyperthermia.

机构信息

Department of Physics, Faculty of Physics, West University of Timişoara, 300223 Timişoara, Romania.

Department of Plastic and Reconstructive Surgery, Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy of Timişoara, 300041 Timişoara, Romania.

出版信息

Int J Mol Sci. 2021 Sep 17;22(18):10071. doi: 10.3390/ijms221810071.

DOI:10.3390/ijms221810071
PMID:34576233
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8470897/
Abstract

Different chemical agents are used for the biocompatibility and/or functionality of the nanoparticles used in magnetic hyperthermia to reduce or even eliminate cellular toxicity and to limit the interaction between them (van der Waals and magnetic dipolar interactions), with highly beneficial effects on the efficiency of magnetic hyperthermia in cancer therapy. In this paper we propose an innovative strategy for the biocompatibility of these nanoparticles using gamma-cyclodextrins (γ-CDs) to decorate the surface of magnetite (FeO) nanoparticles. The influence of the biocompatible organic layer of cyclodextrins, from the surface of FeO ferrimagnetic nanoparticles, on the maximum specific loss power in superparamagnetic hyperthermia, is presented and analyzed in detail in this paper. Furthermore, our study shows the optimum conditions in which the magnetic nanoparticles covered with gamma-cyclodextrin (FeO-γ-CDs) can be utilized in superparamagnetic hyperthermia for an alternative cancer therapy with higher efficiency in destroying tumoral cells and eliminating cellular toxicity.

摘要

不同的化学试剂用于生物相容性和/或功能的磁性热疗中使用的纳米粒子，以减少甚至消除细胞毒性，并限制它们之间的相互作用（范德华力和磁偶极子相互作用），对磁性热疗在癌症治疗中的效率有很大的益处。在本文中，我们提出了一种使用γ-环糊精（γ-CDs）来修饰磁铁矿（FeO）纳米粒子表面的磁性纳米粒子的生物相容性的创新策略。本文详细介绍并分析了生物相容性有机层环糊精从铁氧体铁磁性纳米粒子表面对超顺磁热疗中最大比损耗功率的影响。此外，我们的研究表明，在超顺磁热疗中，用γ-环糊精（FeO-γ-CDs）覆盖的磁性纳米粒子可以在最佳条件下用于替代癌症治疗，以更高的效率破坏肿瘤细胞并消除细胞毒性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fdd/8470897/b10ecd11e7c5/ijms-22-10071-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fdd/8470897/8a210a1165f2/ijms-22-10071-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fdd/8470897/3948a6cde2d0/ijms-22-10071-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fdd/8470897/0ed5d2a6ed39/ijms-22-10071-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fdd/8470897/157a43a56a66/ijms-22-10071-g004a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fdd/8470897/f1a75925e128/ijms-22-10071-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fdd/8470897/b1a6f1bda939/ijms-22-10071-g006a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fdd/8470897/d56f6fcac93f/ijms-22-10071-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fdd/8470897/002946e9bcb7/ijms-22-10071-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fdd/8470897/d77ff8463799/ijms-22-10071-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fdd/8470897/e5b17be1f280/ijms-22-10071-g010a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fdd/8470897/b10ecd11e7c5/ijms-22-10071-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fdd/8470897/8a210a1165f2/ijms-22-10071-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fdd/8470897/3948a6cde2d0/ijms-22-10071-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fdd/8470897/0ed5d2a6ed39/ijms-22-10071-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fdd/8470897/157a43a56a66/ijms-22-10071-g004a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fdd/8470897/f1a75925e128/ijms-22-10071-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fdd/8470897/b1a6f1bda939/ijms-22-10071-g006a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fdd/8470897/d56f6fcac93f/ijms-22-10071-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fdd/8470897/002946e9bcb7/ijms-22-10071-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fdd/8470897/d77ff8463799/ijms-22-10071-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fdd/8470897/e5b17be1f280/ijms-22-10071-g010a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fdd/8470897/b10ecd11e7c5/ijms-22-10071-g011.jpg

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本文引用的文献

[1]
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Optimization Study on Specific Loss Power in Superparamagnetic Hyperthermia with Magnetite Nanoparticles for High Efficiency in Alternative Cancer Therapy.

Nanomaterials (Basel). 2020-12-26

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Therapeutic Efficiency of Multiple Applications of Magnetic Hyperthermia Technique in Glioblastoma Using Aminosilane Coated Iron Oxide Nanoparticles: In Vitro and In Vivo Study.

Int J Mol Sci. 2020-1-31

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