Chen Kuen-Hau, Chen Bor-Chyuan, Ho Ching-Yen
Department of Chinese Medicine, Buddhist Dalin Tzu Chi General Hospital, Chiayi 622, Taiwan.
Department of Mechanical Engineering, Hwa Hsia University of Technology, Taipei 235, Taiwan.
J Nanosci Nanotechnol. 2018 Apr 1;18(4):3018-3023. doi: 10.1166/jnn.2018.14289.
This paper conducts the thermal analysis of magnetic fluid with superparamagnetic nanoparticles subjected to an alternating magnetic field. Magnetic fluid hyperthermia (MFH) provides a potential method for cancer treatment, which has fewer side effects than chemotherapy and radiotherapy. Superparamagnetic nanoparticles dispersed in water are suitable for safe application of MFH. A well-defined hyperthermia should only kill the cancer cells without injuring neighbouring normal tissue. A key factor for hyperthermia is to correctly control the alternating magnetic field-induced temperature of the magnetic fluid in the tumour. Therefore, this study develops a thermal transport model combined with a linear response theory of magnetic nanoparticle (MNP) heat dissipation to analyze the effects of parameters on temperatures in the magnetic fluid with superparamagnetic nanoparticles subjected to an alternating magnetic field. The results predicted by this model are compared with the available experimental data and show that the rise rates of temperature with time and temperatures along the radial direction are enhanced by the increase of MNP concentrations in magnetic fluid, the amplitude of magnetic field strength, frequency, and magnetization.
本文对含有超顺磁性纳米颗粒的磁流体在交变磁场作用下进行了热分析。磁流体热疗（MFH）为癌症治疗提供了一种潜在的方法，其副作用比化疗和放疗更少。分散在水中的超顺磁性纳米颗粒适用于安全的磁流体热疗应用。明确的热疗应该只杀死癌细胞而不损伤邻近的正常组织。热疗的一个关键因素是正确控制交变磁场在肿瘤中引起的磁流体温度。因此，本研究建立了一个热传输模型，并结合磁性纳米颗粒（MNP）散热的线性响应理论，来分析参数对含有超顺磁性纳米颗粒的磁流体在交变磁场作用下温度的影响。该模型预测的结果与现有的实验数据进行了比较，结果表明，磁流体中MNP浓度、磁场强度幅值、频率和磁化强度的增加会提高温度随时间的上升速率以及沿径向的温度。
