Li Rong, Wu Jing, Xiong Liwen, Han Baohui
Shanghai Jiao Tong University School of Medicine, Shanghai, China; Pulmonary Medicine of Shanghai Chest Hospital Ward 12, Shanghai, ChinaThe Biochemical Laboratory of Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Thorac Cancer. 2012 Nov;3(4):303-306. doi: 10.1111/j.1759-7714.2012.00123.x.
Vitamin D deficiency is a global problem.
We examined the 25-hydroxyvitamin D (25(OH)D) concentrations to confirm whether patients with lung diseases in eastern China showed vitamin D deficiency and whether this deficiency was related to the risk of lung cancer. We used chemiluminescence to estimate the 25(OH)D concentrations in 250 patients from eastern China, of whom 197 had untreated stage III/IV lung cancer and 53 had benign lung diseases.
The mean serum 25(OH)D concentration of patients with lung cancer was 10.63 ± 7.04 ng/mL, while the mean serum of patients with benign lung disease was 9.62 ± 6.37 ng/mL. Although there was no significant difference between the values, the mean serum concentrations of 25(OH)D obtained in patients with lung cancer and benign lung diseases were lower than the normal value (>20 ng/mL); P values in both cases were less than 0.0001. Among the 250 patients, 90 showed low serum 25(OH)D levels of ≤4 ng/mL.
Patients with lung diseases in eastern China have low serum levels of 25(OH)D, and the average serum 25(OH)D level is well below the normal vitamin D level. As the average serum 25(OH)D levels in patients with lung cancer or benign lung diseases are very low, we cannot conclude whether the low levels of 25(OH)D are a risk factor for lung cancer.
维生素D缺乏是一个全球性问题。
我们检测了25-羟基维生素D（25(OH)D）浓度，以确定中国东部肺部疾病患者是否存在维生素D缺乏，以及这种缺乏是否与肺癌风险相关。我们采用化学发光法检测了来自中国东部的250例患者的25(OH)D浓度，其中197例为未经治疗的III/IV期肺癌患者，53例为良性肺部疾病患者。
肺癌患者的血清25(OH)D平均浓度为10.63±7.04 ng/mL，而良性肺部疾病患者的血清平均浓度为9.62±6.37 ng/mL。虽然两者之间无显著差异，但肺癌患者和良性肺部疾病患者的血清25(OH)D平均浓度均低于正常值（>20 ng/mL）；两种情况的P值均小于0.0001。在这250例患者中，90例血清25(OH)D水平较低，≤4 ng/mL。
中国东部肺部疾病患者的血清25(OH)D水平较低，且血清25(OH)D平均水平远低于正常维生素D水平。由于肺癌患者或良性肺部疾病患者的血清25(OH)D平均水平非常低，我们无法得出25(OH)D水平低是否为肺癌危险因素的结论。
