Department of Chemistry, Princeton University , Princeton, New Jersey 08544, United States.
Department of Molecular Biology, Princeton University , Princeton, New Jersey 08544, United States.
Org Lett. 2017 Oct 6;19(19):5138-5141. doi: 10.1021/acs.orglett.7b02424. Epub 2017 Sep 18.
The secondary metabolome of the representative Roseobacter, Phaeobacter inhibens, was examined in response to algal sinapic acid. In addition to roseobacticides, sinapic acid induced the production of two new natural products, roseochelin A and B, which were characterized by NMR and X-ray crystallography. Functional assays showed that roseochelin B binds iron and is algaecidal against the algal host Emiliania huxleyi. It appears to be produced by a rarely observed combination of nonenzymatic and enzymatic transformations.
代表玫瑰杆菌属的次级代谢产物，黄杆菌属抑制物，对藻类芥子酸的反应进行了检查。除了玫瑰杆菌菌素外，芥子酸还诱导产生了两种新的天然产物，即玫瑰螯合素 A 和 B，它们通过 NMR 和 X 射线晶体学进行了表征。功能测定表明，玫瑰螯合素 B 结合铁，并且对藻类宿主赫氏海链藻具有杀藻活性。它似乎是由很少观察到的非酶和酶转化组合产生的。
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