海洋微生物含硫天然产物的有趣化学与生物学研究（1987 - 2020年）
The intriguing chemistry and biology of sulfur-containing natural products from marine microorganisms (1987-2020).
作者信息
Hai Yang, Wei Mei-Yan, Wang Chang-Yun, Gu Yu-Cheng, Shao Chang-Lun
机构信息
Key Laboratory of Marine Drugs, School of Medicine and Pharmacy, The Ministry of Education of China, Ocean University of China, Qingdao, 266003 China.
Laboratory for Marine Drugs and Bioproducts, Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao, 266237 China.
出版信息
Mar Life Sci Technol. 2021 May 19;3(4):488-518. doi: 10.1007/s42995-021-00101-2. eCollection 2021 Nov.
UNLABELLED
Natural products derived from marine microorganisms have received great attention as a potential resource of new compound entities for drug discovery. The unique marine environment brings us a large group of sulfur-containing natural products with abundant biological functionality including antitumor, antibiotic, anti-inflammatory and antiviral activities. We reviewed all the 484 sulfur-containing natural products (non-sulfated) isolated from marine microorganisms, of which 59.9% are thioethers, 29.8% are thiazole/thiazoline-containing compounds and 10.3% are sulfoxides, sulfones, thioesters and many others. A selection of 133 compounds was further discussed on their structure-activity relationships, mechanisms of action, biosynthesis, and druggability. This is the first systematic review on sulfur-containing natural products from marine microorganisms conducted from January 1987, when the first one was reported, to December 2020.
SUPPLEMENTARY INFORMATION
The online version contains supplementary material available at 10.1007/s42995-021-00101-2.
未标注
源自海洋微生物的天然产物作为药物发现中新化合物实体的潜在资源受到了极大关注。独特的海洋环境为我们带来了一大类具有丰富生物功能的含硫天然产物，包括抗肿瘤、抗生素、抗炎和抗病毒活性。我们综述了从海洋微生物中分离出的所有484种含硫天然产物（非硫酸化），其中59.9%为硫醚，29.8%为含噻唑/噻唑啉的化合物，10.3%为亚砜、砜、硫酯等。进一步讨论了133种化合物的构效关系、作用机制、生物合成和药物可及性。这是自1987年1月首次报道含硫天然产物以来至2020年12月对海洋微生物含硫天然产物进行的首次系统综述。
补充信息
在线版本包含可在10.1007/s42995-021-00101-2获取的补充材料。
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