Department of Clinical Therapies, University of Limerick, Limerick, Ireland.
St Vincent's University Hospital, Dublin, Ireland.
Mult Scler. 2018 Jun;24(7):995-998. doi: 10.1177/1352458517731912. Epub 2017 Sep 18.
There is a need to identify modifiable risk factors for falls in people with multiple sclerosis (MS) to enable the design of successful falls prevention interventions. There is conflicting evidence regarding the association between medication use and occurrence of falls in MS. A total of 101 people with MS had medications classified using the Anatomical Therapeutic Classification system and number of falls prospectively monitored for 3 months. No association was noted between number of medications and falls. The use of genitourinary and sex hormones (odds ratio (OR) = 5.154, 95% confidence interval (CI) = 1.427-18.609, p = 0.012) and centrally acting muscle relaxant (OR = 5.181, 95% CI = 1.546-17.364, p = 0.008) medications were associated with an increased odds of being a faller.
需要确定多发性硬化症（MS）患者跌倒的可改变风险因素，以便能够设计出成功的跌倒预防干预措施。关于药物使用与 MS 患者跌倒发生之间的关联存在相互矛盾的证据。共有 101 名 MS 患者使用了药物，使用解剖治疗学分类系统进行了分类，并前瞻性地监测了 3 个月的跌倒次数。药物数量与跌倒之间没有关联。使用泌尿生殖和性激素（比值比（OR）= 5.154，95%置信区间（CI）= 1.427-18.609，p = 0.012）和中枢作用肌肉松弛剂（OR = 5.181，95% CI = 1.546-17.364，p = 0.008）药物与跌倒的可能性增加相关。
