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一只成年圈养白点竹鲨(长吻斑竹鲨)上颌前部的鳞状细胞癌

SQUAMOUS CELL CARCINOMA OF THE ROSTRAL MAXILLA IN AN ADULT CAPTIVE WHITESPOTTED BAMBOO SHARK (CHILOSCYLLIUM PLAGIOSUM).

作者信息

Culp Betsy E, Haulena Martin, Britt Kelly, Evans Hannah, Raverty Stephen

出版信息

J Zoo Wildl Med. 2017 Sep;48(3):902-905. doi: 10.1638/2016-0154.1.

Abstract

An approximately 10-yr-old adult female whitespotted bamboo shark (Chiloscyllium plagiosum) presented with a smooth, white, irregular, ulcerated, and expansile lesion on the left lateral aspect of the maxillary rostrum. The lesion had short periods of abrupt and rapid proliferation and then remained static for several months. Cytology and culture were nonspecific and did not reveal any discernible etiologic agents or cellular atypia. The lesion was nonresponsive to parenteral antibiotics. One year after the initial onset of the lesion, the ulcer was 10 cm in diameter, a percentage increase in size of 455%. Due to a protracted clinical course and lack of response to medication and supportive care, coupled with an acute onset of neurologic signs and self-inflicted trauma, the shark was euthanized. Histopathology of the mass disclosed a locally invasive squamous cell carcinoma with no evidence of metastasis.

摘要

一只约10岁的成年雌性白点竹鲨(Chiloscyllium plagiosum)上颌吻突左侧出现一个光滑、白色、不规则、溃疡且扩展性的病变。该病变有短时间的突然快速增殖期,然后会持续数月保持静止。细胞学检查和培养结果均无特异性,未发现任何可识别的病原体或细胞异型性。该病变对注射用抗生素无反应。病变最初出现一年后,溃疡直径达10厘米,大小增加了455%。由于病程迁延、对药物和支持治疗无反应,再加上急性神经症状发作和自残创伤,这只鲨鱼被实施安乐死。肿块的组织病理学检查显示为局部浸润性鳞状细胞癌,无转移迹象。

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