脊椎动物中癌症的发生：一篇小型综述。
The occurrence of cancer in vertebrates: a mini review.
作者信息
Kitsoulis Christos V, Baxevanis Athanasios D, Abatzopoulos Theodore J
机构信息
Department of Genetics, Development & Molecular Biology, School of Biology, Faculty of Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
出版信息
J Biol Res (Thessalon). 2020 Jun 8;27:9. doi: 10.1186/s40709-020-00119-0. eCollection 2020 Dec.
Neoplasia is a multilevel condition caused by irregularities over the genome, which can lead to a fatal result. To fully understand this phenomenon, an evolutionary challenge has risen during the last decades, away from human limits, driving the scientific quest into the wild life. The study of wild vertebrate populations in their natural habitats has shown that cancer is rather prominent. Thus, the diversity of vertebrates reported with some form of neoplasia is quite scattered through a variety of habitats. However, some species constitute exceptions by exhibiting cancer-protective features, driven by certain loci in their DNA. It is obvious that from an evolutionary standpoint, the incidence of cancer in different taxa is nowadays studied by seeking for patterns and their roots. The main purpose of the evolutionary approach is no other than to answer a fundamental question: Could cancer be ultimately regarded as another evolutionary force conducive to the formation or shaping-up of species?
肿瘤形成是一种由基因组异常引起的多层面病症，可能导致致命后果。为了全面理解这一现象，在过去几十年里出现了一项超越人类局限的进化挑战，推动科学探索深入到野生动物领域。对自然栖息地中野生脊椎动物种群的研究表明，癌症相当普遍。因此，报告患有某种形式肿瘤的脊椎动物种类在各种栖息地中分布相当分散。然而，一些物种通过展现出由其DNA中的某些基因座驱动的癌症保护特征而成为例外。显然，从进化的角度来看，如今通过寻找模式及其根源来研究不同分类群中癌症的发病率。进化方法的主要目的无非是回答一个基本问题：癌症最终能否被视为另一种有助于物种形成或塑造的进化力量？
Zotero 插件