Sladek N E, Domeyer B E, Merriman R L, Brophy G T
Drug Metab Dispos. 1978 Jul-Aug;6(4):412-7.
Walker 256 rat carcinosarcoma cells growing as solid subcutaneous or intramuscular tumors depressed hepatic microsomal mixed-function oxygenase activity to less than 20% of control activity, but the same tumor cells growing as free ascites cells in the peritoneal cavity did not. Necrosis of the core area of solid tumors was observed. Tumor cells may release a substance that depresses hepatic microsomal mixed-function oxygenase activity only upon their death.
Walker 256大鼠癌肉瘤细胞在皮下或肌肉中形成实体瘤时，会使肝微粒体混合功能氧化酶活性降低至对照活性的20%以下，但在腹腔中以游离腹水细胞形式生长的相同肿瘤细胞则不会。观察到实体瘤核心区域出现坏死。肿瘤细胞可能仅在死亡时才会释放一种可降低肝微粒体混合功能氧化酶活性的物质。
