烦躁不安的生化方面：用于假设生成的案例研究。

Biochemical aspects of dysphoria: case study for hypothesis generation.

作者信息

Kruzik P, Sofic E, Riederer P, Gabriel E

机构信息

Institute of Medical Chemistry, University of Veterinary Medicine, Vienna, Austria.

出版信息

Psychopathology. 1987;20(2):120-7. doi: 10.1159/000284489.

DOI:10.1159/000284489

PMID:2892224

Abstract

Comparing the pattern of serotonin, 5-hydroxyindole acetic acid, 3,4-dihydroxyphenyl acetic acid and homovanillic acid in five brain areas of one dysphoric patient to those of 3 depressed patients it seems that dysphoria biochemically is a state between depression and mania. Dynamically, dysphoria may possibly be seen as a behavioral correlate of a switch process between high and low turnover of neurotransmitters (rather high frequency in comparison to bipolar disorder with very low frequency). However, the biochemical data are obviously in agreement with psychiatric findings, i.e. that dysphoria in any case is an extremely labile state.

摘要

将一名烦躁不安患者五个脑区中血清素、5-羟吲哚乙酸、3,4-二羟基苯乙酸和高香草酸的模式与三名抑郁症患者的模式进行比较后发现，从生化角度来看，烦躁不安似乎是抑郁和躁狂之间的一种状态。从动态角度看，烦躁不安可能被视为神经递质高转换率和低转换率之间转换过程的行为关联（与双相情感障碍的极低频率相比，频率相当高）。然而，生化数据显然与精神病学研究结果一致，即无论如何，烦躁不安都是一种极其不稳定的状态。