McDaniel D O, Barger B O, Reveille J D, Alarcón G S, Koopman W J, Acton R T
Department of Medicine, School of Medicine, University of Alabama, Birmingham.
Rheum Dis Clin North Am. 1987 Aug;13(2):353-67.
Considerable evidence indicates that genes residing within the major histocompatibility complex (MHC) influence susceptibility to certain rheumatic diseases, such as ankylosing spondylitis (AS) and rheumatoid arthritis (RA). However, it has not yet been possible to precisely identify the gene(s) responsible for conferring enhanced susceptibility to these diseases. The availability of recombinant DNA technology should accelerate progress in obtaining this goal. A particularly promising method in this regard is restriction fragment length polymorphism (RFLP) analysis using appropriate class I and class II MHC gene probes. In preliminary studies, RFLPs have been identified for AS and RA which associate with susceptibility to the disease. Further studies using this approach should permit localization and precise identification of the disease susceptibility gene(s) for these diseases.
大量证据表明，位于主要组织相容性复合体（MHC）内的基因会影响对某些风湿性疾病的易感性，如强直性脊柱炎（AS）和类风湿关节炎（RA）。然而，目前尚无法精确鉴定赋予这些疾病更高易感性的基因。重组DNA技术的出现应能加速实现这一目标的进程。在这方面，一种特别有前景的方法是使用合适的I类和II类MHC基因探针进行限制性片段长度多态性（RFLP）分析。在初步研究中，已确定与AS和RA相关的RFLP，这些RFLP与疾病易感性相关。使用这种方法的进一步研究应能定位并精确鉴定这些疾病的疾病易感性基因。
