强直性脊柱炎家族中HLA I类基因的Taq I多态性
Taq I polymorphism of HLA class I genes in an ankylosing spondylitis family.
作者信息
Lucotte G, Huetz F, Mariotti M, Cavelier B, Deshayes P, Amor B
机构信息
Laboratory of Molecular Genetics, National Blood Transfusion Center Institute, Paris, France.
出版信息
Exp Clin Immunogenet. 1987;4(4):207-10.
PMID:2908513
Abstract
A 3.5-kb HLA class I fragment is polymorphic in an ankylosing spondylitis (AS) family. All B27 AS patients show the 3.5-kb band, which is also present in B12 AS patients in this family. When hybridized with an HLA-B-specific probe, the polymorphic band is revealed in B12 patients, but not in B27 patients.
摘要
一个3.5千碱基对的HLA I类片段在一个强直性脊柱炎（AS）家族中具有多态性。所有B27 AS患者都显示出3.5千碱基对的条带，该家族中的B12 AS患者也有此条带。当与HLA - B特异性探针杂交时，多态性条带出现在B12患者中，而在B27患者中未出现。
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