State Key Laboratory of Applied Organic Chemistry, Lanzhou University Gansu and Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province , Lanzhou 730000, People's Republic of China.
Zhongwei High-Tech Institute of Lanzhou University , Zhongwei, Ningxia 755500, China.
J Org Chem. 2017 Nov 3;82(21):11505-11511. doi: 10.1021/acs.joc.7b02105. Epub 2017 Oct 2.
A rhodium-catalyzed intermolecular coupling between arylnitrones and diazo compounds by C-H activation/[4 + 1] annulation with a C(N)-C(acyl) bond cleavage is reported, and 2,3-disubstituted NH indoles are directly synthesized in up to a 94% yield. A variety of functional groups are applicable to this reaction to give the corresponding products with high selectivity. Compared to other previously reported Rh(III)-catalyzed synthesis of homologous series, this method is simpler, more general, and more efficient.
报道了铑催化的芳基硝酮与重氮化合物通过 C-H 活化/[4+1]环加成反应的分子间偶联反应，其中 C(N)-C(酰基)键断裂，直接合成了 2,3-二取代的 NH 吲哚，产率高达 94%。该反应可适用于多种官能团，以高选择性得到相应产物。与其他先前报道的 Rh(III)催化的同系物合成方法相比，该方法更简单、更通用、更高效。
