Kubba M A, McNicol A M
University Department of Pathology, Royal Infirmary, Glasgow, Scotland.
Virchows Arch B Cell Pathol Incl Mol Pathol. 1987;54(2):119-26. doi: 10.1007/BF02899203.
The ultrastructural changes occurring in the corticotrophs of adult male and female Sprague-Dawley rats at 2 and 6 weeks after bilateral adrenalectomy were assessed on both a qualitative and quantitative basis. Qualitative changes were similar to those previously described but at both time points, female rats showed more marked changes than males. Corticotroph hypertrophy reached a plateau in male animals between 2 and 6 weeks, but continued to increase in females. There was an increase in mean granule diameter in both sexes at 2 weeks after adrenalectomy. The changes induced by the daily administration of CRF for 2 weeks by intraperitoneal injection were also examined in male rats. CRF induced corticotroph hypertrophy at both 25 micrograms/Kg and 50 micrograms/Kg body weight and increased the granule content. The addition of vasopressin (VP) to the higher dose of CRF induced a further increase in cell area and reduction in granule content. Low dose CRF was associated with an increase in mean granule diameter, whereas a decrease was seen after high dose.
在双侧肾上腺切除术后2周和6周，对成年雄性和雌性Sprague-Dawley大鼠促肾上腺皮质激素细胞的超微结构变化进行了定性和定量评估。定性变化与先前描述的相似，但在两个时间点，雌性大鼠的变化都比雄性更明显。促肾上腺皮质激素细胞肥大在雄性动物中在2至6周之间达到稳定状态，但在雌性中持续增加。肾上腺切除术后2周，两性的平均颗粒直径均增加。还对雄性大鼠腹腔注射CRF 2周所引起的变化进行了研究。CRF在25微克/千克和50微克/千克体重时均诱导促肾上腺皮质激素细胞肥大，并增加颗粒含量。在较高剂量的CRF中添加血管加压素（VP）会导致细胞面积进一步增加，颗粒含量减少。低剂量CRF与平均颗粒直径增加有关，而高剂量后则出现减少。
