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Refined karyotype-based prognostic stratification of chronic lymphocytic leukemia with a low- and very-low-risk genetic profile.

作者信息

Giudice I Del, Rigolin G M, Raponi S, Cafforio L, Ilari C, Wang J, Bordyuh M, Piciocchi A, Marinelli M, Nanni M, Tavolaro S, Filetti M, Bardi A, Tammiso E, Volta E, Negrini M, Saccenti E, Mauro F R, Rossi D, Gaidano G, Guarini A, Rabadan R, Cuneo A, Foà R

机构信息

Hematology, Department of Cellular Biotechnologies and Hematology, Policlinico Umberto I, Sapienza University, Rome, Italy.

Hematology Section, Azienda Ospedaliera Universitaria Arcispedale S. Anna, University of Ferrara, Ferrara, Italy.

出版信息

Leukemia. 2018 Feb;32(2):543-546. doi: 10.1038/leu.2017.292. Epub 2017 Sep 19.

DOI:10.1038/leu.2017.292
PMID:28924243
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5898432/
Abstract
摘要

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Refined karyotype-based prognostic stratification of chronic lymphocytic leukemia with a low- and very-low-risk genetic profile.基于精细核型分析的低风险和极低风险基因特征慢性淋巴细胞白血病的预后分层
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[Correlation between karyotype and prognosis in adult lymphocytic leukemia].[成人淋巴细胞白血病的核型与预后的相关性]
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Culture conditions in chronic lymphocytic leukemia: relationship to karyotype.慢性淋巴细胞白血病的培养条件：与核型的关系
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The parallel application of karyotype interphase and metaphase FISH after DSP-30/IL-2 stimulation is necessary for the investigation of chronic lymphocytic leukemia.在DSP-30/IL-2刺激后，并行应用核型间期和中期荧光原位杂交技术对于慢性淋巴细胞白血病的研究是必要的。
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Karyotypic complexity rather than chromosome 8 abnormalities aggravates the outcome of chronic lymphocytic leukemia patients with TP53 aberrations.核型复杂性而非8号染色体异常会加重伴有TP53畸变的慢性淋巴细胞白血病患者的预后。
Oncotarget. 2016 Dec 6;7(49):80916-80924. doi: 10.18632/oncotarget.13106.
2
Extensive next-generation sequencing analysis in chronic lymphocytic leukemia at diagnosis: clinical and biological correlations.慢性淋巴细胞白血病诊断时的广泛二代测序分析：临床与生物学相关性
J Hematol Oncol. 2016 Sep 15;9(1):88. doi: 10.1186/s13045-016-0320-z.
3
Survival of Del17p CLL Depends on Genomic Complexity and Somatic Mutation.17p缺失慢性淋巴细胞白血病的生存取决于基因组复杂性和体细胞突变。
Clin Cancer Res. 2017 Feb 1;23(3):735-745. doi: 10.1158/1078-0432.CCR-16-0594. Epub 2016 Aug 8.
4
Complex karyotypes and KRAS and POT1 mutations impact outcome in CLL after chlorambucil-based chemotherapy or chemoimmunotherapy.基于苯丁酸氮芥的化疗或化疗免疫治疗后，复杂核型和 KRAS 及 POT1 突变影响 CLL 的预后。
Blood. 2016 Jul 21;128(3):395-404. doi: 10.1182/blood-2016-01-691550. Epub 2016 May 25.
5
Complex karyotype is a stronger predictor than del(17p) for an inferior outcome in relapsed or refractory chronic lymphocytic leukemia patients treated with ibrutinib-based regimens.对于接受基于伊布替尼方案治疗的复发或难治性慢性淋巴细胞白血病患者，复杂核型比17号染色体短臂缺失（del(17p)）更能预示不良预后。
Cancer. 2015 Oct 15;121(20):3612-21. doi: 10.1002/cncr.29566. Epub 2015 Jul 20.
6
Genomic complexity and IGHV mutational status are key predictors of outcome of chronic lymphocytic leukemia patients with TP53 disruption.基因组复杂性和IGHV突变状态是TP53基因破坏的慢性淋巴细胞白血病患者预后的关键预测指标。
Haematologica. 2014 Nov;99(11):e231-4. doi: 10.3324/haematol.2014.108365. Epub 2014 Jul 4.
7
Clinical impact of small TP53 mutated subclones in chronic lymphocytic leukemia.慢性淋巴细胞白血病中小 TP53 突变亚克隆的临床影响。
Blood. 2014 Apr 3;123(14):2139-47. doi: 10.1182/blood-2013-11-539726. Epub 2014 Feb 5.
8
Chlorambucil plus rituximab with or without maintenance rituximab as first-line treatment for elderly chronic lymphocytic leukemia patients.苯丁酸氮芥联合利妥昔单抗一线治疗老年慢性淋巴细胞白血病患者：是否加用维持治疗利妥昔单抗。
Am J Hematol. 2014 May;89(5):480-6. doi: 10.1002/ajh.23668. Epub 2014 Feb 18.
9
Genetic subclonal complexity and miR125a-5p down-regulation identify a subset of patients with inferior outcome in low-risk CLL patients.基因亚克隆复杂性和miR125a - 5p下调可识别低风险慢性淋巴细胞白血病患者中预后较差的一个亚组。
Oncotarget. 2014 Jan 15;5(1):140-9. doi: 10.18632/oncotarget.1382.
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Chromosomal translocations and karyotype complexity in chronic lymphocytic leukemia: a systematic reappraisal of classic cytogenetic data.慢性淋巴细胞白血病中的染色体易位和核型复杂性：对经典细胞遗传学数据的系统再评价。
Am J Hematol. 2014 Mar;89(3):249-55. doi: 10.1002/ajh.23618.