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低风险甲状腺微小乳头状癌的新范式:主动监测

A new paradigm in low-risk papillary microcarcinoma: active surveillance.

作者信息

González Bóssolo Alex, Garcia Michelle Mangual, González Paula Jeffs, Garcia Miosotis, Villarmarzo Guillermo, Martinez Jose Hernán

机构信息

Endocrinology, Diabetes and Metabolism.

Endocrinology.

出版信息

Endocrinol Diabetes Metab Case Rep. 2017 Sep 4;2017. doi: 10.1530/EDM-17-0065. eCollection 2017.

Abstract

UNLABELLED

Classical papillary thyroid microcarcinoma (PTMC) is a variant of papillary thyroid carcinoma (PTC) known to have excellent prognosis. It has a mortality of 0.3%, even in the presence of distance metastasis. The latest American Thyroid Association guidelines state that although lobectomy is acceptable, active surveillance can be considered in the appropriate setting. We present the case of a 37-year-old female with a history of PTMC who underwent surgical management consisting of a total thyroidectomy. Although she has remained disease-free, her quality of life has been greatly affected by the sequelae of this procedure. This case serves as an excellent example of how first-line surgical treatment may result more harmful than the disease itself.

LEARNING POINTS

Papillary thyroid microcarcinoma (PTMC) has an excellent prognosis with a mortality of less than 1% even with the presence of distant metastases.Active surveillance is a reasonable management approach for appropriately selected patients.Patients should be thoroughly oriented about the risks and benefits of active surveillance vs immediate surgical treatment. This discussion should include the sequelae of surgery and potential impact on quality of life, especially in the younger population.More studies are needed for stratification of PTMC behavior to determine if conservative management is adequate for all patients with this specific disease variant.

摘要

未标注

经典型甲状腺微小乳头状癌(PTMC)是甲状腺乳头状癌(PTC)的一种变异型,已知其预后良好。即使存在远处转移,其死亡率也仅为0.3%。美国甲状腺协会最新指南指出,虽然肺叶切除术是可以接受的,但在适当情况下可考虑积极监测。我们报告一例37岁有PTMC病史的女性患者,她接受了包括全甲状腺切除术在内的手术治疗。尽管她一直无病生存,但该手术的后遗症对其生活质量产生了极大影响。该病例很好地说明了一线手术治疗可能比疾病本身更具危害性。

学习要点

甲状腺微小乳头状癌(PTMC)预后良好,即使存在远处转移,死亡率也低于1%。

对于适当选择的患者,积极监测是一种合理的管理方法。

应让患者充分了解积极监测与立即手术治疗的风险和益处。这种讨论应包括手术的后遗症以及对生活质量的潜在影响,尤其是在年轻人群中。

需要更多研究对PTMC的行为进行分层,以确定保守治疗是否适用于所有患有这种特定疾病变异型的患者。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dd9/5592700/4cec00476657/edmcr-2017-170065-g001.jpg

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