Plaitakis A, Caroscio J T
Mount Sinai School of Medicine of the City University of New York, NY 10029.
Ann Neurol. 1987 Nov;22(5):575-9. doi: 10.1002/ana.410220503.
Glutamate levels were determined in the fasting plasma of 22 patients with early-stage primary amyotrophic lateral sclerosis (ALS) and compared to those of healthy and diseased controls. There was a significant increase (by approximately 100%, p less than 0.0005) in the plasma glutamate of the ALS patients as compared with the controls. Oral glutamate loading (60 mg of monosodium glutamate per kilogram of body weight, taken orally after overnight fasting) resulted in significantly greater elevations in the plasma glutamate and aspartate levels in the ALS patients than in the controls. Glutamate, a potentially neuroexcitotoxic compound, is thought to be the transmitter of the corticospinal tracts and certain spinal cord interneurons. A systemic defect in the metabolism of this amino acid may underlie primary ALS.
在22例早期原发性肌萎缩侧索硬化症（ALS）患者的空腹血浆中测定了谷氨酸水平，并与健康对照者和患病对照者的水平进行了比较。与对照组相比，ALS患者血浆谷氨酸水平显著升高（约升高100%，p<0.0005）。口服谷氨酸负荷试验（禁食一夜后口服每千克体重60毫克味精）导致ALS患者血浆谷氨酸和天冬氨酸水平的升高幅度明显大于对照组。谷氨酸是一种潜在的神经兴奋性毒性化合物，被认为是皮质脊髓束和某些脊髓中间神经元的递质。这种氨基酸代谢的系统性缺陷可能是原发性ALS的基础。
